Prejudice against any subject was something that I did not like to have in the past. Now depending on my relationship with the person, I won't approach certain issues that I know upsets them in any way. So it really does depend on who you're talking to. I know the common knowledge is to not speak about politics or religion with friends and though I can understand where that comes from, I do feel like it makes the most interesting of conversations. This is if people don't become emotional and offensive.
Personally I'm open to talk about anything that anyone wants to talk to me about if it's centered around them or they are asking my opinion on the topic.