It all depends on what type of superhero you want to be.
Should you choose to be one of the gamma radiation type of heroes, you could be risking a bout of cancer.
Spider bites from an radioactive spider can hurt like the dickens.
If you love your parents, you may not want them mugged for your mom's pearls.
Being blind is risky if you want to fight with the tell tale radar sense.
You'd have more of a chance of winning the lottery than having the Guardians of the Universe selecting you for a power ring.
Best stick with the guns, working out, and homicidal hatred of bad guys... That's the most direct route.