I would have to give votes to the Joker from Batman, Pennywise from Stephen King's novel IT, and Emperor Palpatine from the Star Wars saga.
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I always feel like answering this question with Vader, but then I remember that he was manipulated the whole time. If you only follow the original trilogy however, he definitely takes the cake.
the three originals were my favorites (books and movies) I saw the three newer ones but did not really like them as much. Plus Add Mr gaunt from Needful Things (Stephen King)
Very nice. I did not even think of Mr. Lecter when posing the question, despite the fact he has always been one of my favorites.