It's pretty easy to self-publish just about anything. I use CreateSpace to publish my books and 'zines, and they go right up on Amazon as soon as they're finished. CreateSpace takes care of all the printing and shipping, and pays me a royalty each time a copy is sold.
I use Publisher to set up my books, because I combine text and artwork. If you're doing text only, you can set it up in Word, and it's also much easier to convert your book to something that's Kindle ready.