If you are fortunate to have plenty of vacation days along with a job where you don't have to give notice beyond a few days that you'll be using some time then one could sign up with http://www.travelzoo.com/
All three of these sites offer "last minute" deals.
Most of the Apple Vacations are for all inclusive resorts which include airfare, food, alcohol/drinks. Duration of the trips may be as little as 3 days and up to 12.
Travelzoo and Pricline also will send alerts for your local area or region. For example someone living in San Diego, CA (Southern California) may get an alert for special to fly up to San Francisco for a weekend along with a special hotel rate.
Lastly you act like a tourist in your own town or nearest large city to you. Check out http://www.citypass.com/ for deals on various tourist attractions, most likely there hotel specials.
You may sign up to recieve alerts from starwood hotels, Hyatt, Kimpton, and Marriott...etc. You could stay downtown, ride around in a double deck open air tour bus, or take a taxi to the various attractions, turn off your cell phone, avoid watching the news or reading a newspaper, eat at nice restaurants, dance, see a play, or take in a movie.
On Sunday have a leisurely champagne brunch before heading home. By the time it's all said and done you'll fell like you had a mini vacation!