Absolutely! I save 50% to 75% at the grocery store. One of the stores I go to triples coupons up to $0.99 several times per year. It also does Super Double Coupons where coupons up to $1.00 are doubled. On a daily basis, it doubles coupons up to $0.99. Depending on the situation, sometimes you can make a profit on the coupon matchups which allows you to put the overage towards produce and meat, or anything you don't have a coupon for... so it is worth it!
I use forums/websites that tell me what coupons match up to sales in my area so that I can skip the research and just cut and print the coupons I need. Many of the sites actually post store inserts a week or two in advance.