No. Although she is a very loving and generous person I feel she lacks the ability to navigate the political waters.
One reason many successful people fail as politicans is because unlike a business where one person gets to call the shots as though they were the 10 commandments....etc A politician is forced to compromise over and over again just to get some of what she/he wants in return.
There will always be an opposition party whose sole responsibility is to tear you down on a daily basis. That's just comes with the territory. Awhile back I wrote a hub stating that "political gridlock" is the American way. https://hubpages.com/politics/politicalgridlockisw...
I don't believe Oprah could stand that type of heat. Thankfully she knows what her strengths are.