Hello. Good, thought provoking question.
Personally I would say that there is little liklihood of a Civil War occurring across the US.
The Revolution, which may be considered as a civil war, and the Civil War of 1861-65, had particular causes. for the Revolution, home rule if not independence and the states rights or slavery question for the Civil War. You mention several questions of difference and as Pintoman says even those divisive questions in turn divide people.
In general the US Constitution is based on pragmatism, common sense, compromise and right thinking. There are times when the country has divided into camps for or against on many subjects, there is then a lot of noise and finger pointing and then the good sense kicks in and people begin generally to work towards a common goal.
With all that the world has gone through in the last decade, the US has held strong, some nations have seen near or actual revolutions on their streets and gone to the brink of chaos.
We see the right to be different in many ways as a good thing, I don't have to think as you do and I have no right to impose my thoughts on you. We can however agree to discuss, debate and persuade, and come to a common agreement to agree or disagree. In the end this releases the pressure which might over spill into fighting.