Ok, so let's be practical about this. I'm a rural westerner so guns aren't the big bugaboo they are in your larger cities. In my mind a firearm is just a tool like any other. "The right tool for the right job" I always say. So, for starters handguns are out. I've seen more danged fools shoot themselves or someone they love with one and frankly, I don't see the need for them. For practicality sake I'd go with the 12 gauge Sega. It can be used to hunt birds such as duck and pheasant; with slugs it makes a fair deer hunting piece of you can get in close enough so a person will need some hunting skills to make any true use of it. For personal protection it would be very effective, if a bit messy, and wouldn't have the tendency to penetrate multiple walls like the more high powered handguns and rifles do.
Growing up in my home we had 6 firearms. My dad had his 30.06 and 12 gauge double barrel-one for large game and one fowling piece-and a .357 magnum handgun. Not for protection, just in case that deer you dropped wasn't quite dead yet and at close range the .06 would blood shoot the meat and ruin it. There was an old Remington .22 for general target plinking and the occasional rodent control. That was the gun I learned to shoot with and take care of until I got my first 30.30 repeater. A good gun for hunting at close range as it was light and rugged, a handy thing in mountainous terrain or dense brush, but could still bring down a deer in one shot. My sister had a little single shot .410 that was good for small game such as rabbit or chukkar and the odd rattle snake. Everyone I knew had a similar number and types at home. It was no big deal.