If meant off-grid like Jodah shared, then yes. If meant will urban areas be eliminated, then no. I don't think it is an issue of humans per se. It is an issue of population. Individuals can change. If enough then collectively too. It seems the question asks if there can be a better balance between humans today with earth's nature - ecology, (If that is what is meant by nature) as it is today. Most certainly.
Scientist / author Jared Diamond offers some insight into this question. From some of my reading looking for an answer I decided this answer. The first time a human plowed a furrow nature lost its virginity. Simultaneously animals were domesticated. Nature lost again. No other animal planted plants and harvested them for food to my knowledge and understanding today. No other animal domesticated animals. I dun'no . . . In an odd sense it has the same implication as the GMO arguments. Nature was altered for the benefit of humans.
An interesting article by Jared Diamond to read at Discover Magazine is at this link: http://discovermagazine.com/1987/may/02-the-worst-...
Here is a link to a more detailed article by the same author: http://www.ditext.com/diamond/mistake.html