If I won a great big lottery right now, I think I would buy a helicopter to ferry supplies to the Puerto Rican hurricane victims who are not receiving aid right now. (Why is the government not sending in these supplies by helicopter to areas that are unreachable?)
My heart really lies with the animals so I would donate to all the local animal shelters in the county.
Veterans organizations and their projects.
Public arts (I agree with Lisa) that these are always the first to go in federal budget cuts)
Arkansas Children's Hospital (iin addition to children, it specializes in burn victims and adult burn patients are sent there) and maybe St. Jude's Hospital that helps ill children without charging them.
Note: Why not Habitat for Humanity? because while it sounds like a great idea, it helps only one person or family at a time, and there are many government handout organizations that already help with welfare-type housing.