I can't see it happening. She doesn't have much experience. Also, her VP campaign revealed her weaknesses. Namely, that she does not know very much. They tried to hide her weaknesses during that campaign by not allowing her to talk very often off script. In a presidential campaign, that would be harder to do.
I also expect President Obama's political fortunes to improve by 2012. The economy should be somewhat better by then, and now that Republicans are much stronger in Congress, they can't simply blame him for everything.
Here are some other 2011 predictions: