You were made in God's image. That gives you worth. Christ suffered and died for you. That gives you significance. If you haven't found your gift yet, be patient and take steps to seek it out. Your significance is not reflected in the opinions of human beings; your significance exists because you exist, and part of your responsibility is to embrace it, understand it, develop it, and give God the credit. You need not have national or global impact; you need only touch one life to make a difference, and often you will not be aware that you've done so, because the impression or lesson you provide will develop in your absence.