I worry that I will never be able to really cut loose and live life to the fullest. I had a rough childhood, but at least I was able to escape the ghetto 2 weeks a year when I went to summer camp. My greatest desire was to live like that all the time as an adult, but I have done an extremely poor job of it. I am now trying to use the principles of The Secret to attract it, and am making some progress. I hope to retire early so I can enjoy life while I'm still healthy and vibrant. Fortunately, I've inherited good genes towards that end, so that's a possibility.
Regarding whether or not the world is going to hell in a hand basket - I doubt it. The problems we face today aren't nearly as bad as they were in the past. For example, Ebola is horrible, but at least we know what causes it, and how to avoid contracting it. Compare that with the bubonic plague that wiped out a third of Europe in the Dark Ages. They had NO IDEA what was going on, or what to do about it. The cause and cure wasn't even discovered until 1896.
I believe our greatest concern is global warming. However, I'm confident we'll find a solution for that.