Tom Brady holds the record for most TD's thrown in a season. He's the one who threw 50 TD's in 2007. Peyton Manning threw 49 in 2004, and that was the record until Brady threw 50 in 2007. But anyway, Peyton has 12 through three games this year, an average of four TD's per game. He's on pace to throw 64 TD's this year. But he will most likely cool down at least a little bit. I think more than 50 is definitely possible for Peyton this year, especially because of the inflation in QB stats over the last 10 years. QB's are throwing for more yards, more TD's, and more completions and at a better completion percentage than ever before. The game is so much more focused on offense and on passing the ball now.