It depends on what type of fish your targeting, but in general...
1. Use live bait
2. Start our easy, go for some blue gill or catfish
3. When you feel a nibble don't try to hook the fish yet, you'll know when he takes the bait.
4. Don't reel in the line when it's tight
5. Don't be afraid to get your hands dirty, that fish won't take the hook out himself.