I think that the best wrinkle cream, depends on many factors. One of the most important is the type of your skin.
Anyway I wouldn't recommend something that is more chemical than natural. It's not the human.
Another thing you should consider, is the long term results or short term. If you want to be wrinkle free for the long term, you want to use a totally different product than the cream that will make you look 10 years longer, but just for a few hours.
In conclusion I prefer to say, that there isn't a general best cream, but there is my best cream, that works for me.
Try a few, and stick with the one that is for you.