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Botox or Dysport?
The Botox Miracle
BotoxÂ® has been used effectively for cosmetic purposes in the United States for a number of years now whereas DysportÂ® has just been approved for use(although is has been used safely for many years throughout Europe, Brazil and more than 26 other countries worldwide) and is now (as of July 2009) available at your doctors office alongside BotoxÂ®.
Although they are similar in function, they are not the same drug, they have different dosages and different possible side effects. It's up to you to be informed when selecting between the two and hopefully after reading this page you will be.
photo source: http://www.babychums.com/wp-content/uploads/2009/01/botox_injection_female.jpg
History And Possible Side Effects Of Botox
Botox is defined as a purified botulinum toxin type A, produced from fermentation of Hall strainClostridium botulinum type A grown in a medium containing casein hydrolysate, glucose and yeast extract. It is purified from the culture solution by dialysis and a series of acid precipitations to a complex consisting of the neurotoxin, and several accessory proteins. The complex is dissolved in sterile sodium chloride solution containing Albumin Human and is sterile filtered (0.2 microns) prior to filling and vacuum-drying. http://www.rxlist.com/botox-drug.htm
Botox has an interesting history that all began with sausage in the 1820's. A German physician, Dr. Justinus Kerner began some experiments to determine what caused the deaths of some Germans who had consumed sausage. Turns out it was food-borne botulism. Then in 1895 Dr. Emile Van Ermengem from Belgium was the first to isolate the bacterium, and in 1944 Dr. Edward Schantz cultured Clostridium botulinum and isolated the toxin. And finally in 1949, it was discovered that botulinum toxin blocks neuromuscular transmission. In the 1950s and 60's purified botulinum toxin type A into crystalline form was synthesized and it was discovered that small doses of botulinum relax muscles temporarily. In the 1950s the toxin started to be used experimentally as a medical cosmetic treatment on politicians, one of which was said to be the actor and former United States President, Ronald Regan. The 70's and 80's brought many experiments, mostly on animals with the toxin.
Finally, in 1989-a year after the company Allergen bought the distribution rights to the toxin-the FDA approved botulinum toxin type A for treating crossed eyes and spasms in the eye muscle. Soon after than Botox was born. As more research was conducted in the 1990s, it was uncovered that Botox temporarily cured excessive sweating and cerebral palsy. Then ophthalmologist Dr. Jean Carruthers noticed her patients treated with Botox were looking fabulously wrinkle-free. She and he husband, (a dermatologist) published a study on Botox's ability to decrease frown lines and after that Botox took off as a cosmetic treatment. So much so that in the late 90's they even ran out of it temporarily.
POTENTIAL SIDE EFFECTS
As with any drug, side effects are possible. Most people however, do not experience any and tolerate the drug quite well. If side effects do occur they are usually very mild.
Botox has been studied thoroughly in clinical trials. In these studies, common side effects included: droopy eyelids, nausea ,muscle weakness, facial pain, indigestion, tooth problems,high blood pressuire, flu-like symptoms, such as a fever and chills, dizziness, weakness, infection or bleeding at the injection site.
Some side effects with Botox, while occurring infrequently, are potentially serious and should be reported to your healthcare provider right away. These include but are not limited to: chest pain, difficulty swallowing, speech problems, dry eyes or eye pain, double vision, signs of an allergic reaction such as rash, hives, itching, wheezing, swelling.
Recently there has been news of Botox possibly being able to spread beyond the site of injection, potentially causing botulism poisoning. Accusations against Botox earlier this year led the FDA to mandate black box warnings for the popular drug, however it is inconclusive as to whether or not this can actually happen as of yet.
photo source: http://www.realself.com/files/imagecache/blog/injection-28513.jpg
History And Possible Side Effects Of Dysport
Like Botox, Dysport is a lyophilized form of the botulinum toxin type. The difference is that a vial of Dysport contains 500 Units of toxin and 125 micrograms of albumin, and is typically diluted to 200 U/mL. The Botox vial contains 100 Units of toxin and 500 micrograms of albumin, and is typically diluted to 25-50 U/mL. Dysport works in the same way Botox does by preventing muscle contraction and weakening the muscles.
The early 90's when Dyspoirt first came into use as a treatment for muscle spasms in the UK. Like Botox, it was then discovered that Dysport could effectively remove wrinkles and facial creases as well, the treatment was distributed in Europe and several other countries around the world.
In 2006, Dysport's manufacturer, Ipsen, joined forces with the U.S. pharmaceutical group, Medicis, to distribute the product in the U.S. and Canada. The U.S. branding of Dysport was originally going to be Reloxin, but the FDA mandated that the drug be branded under its original name of Dysport. most news and online sources, originally discussed it under the name Reloxin.
Currently Dysport is the only other injectable type in Botox's class giving Botox some stiff and much needed competition. I say this because Botox is very expensive. Currently, the cost of Botox injections can range from $300 to $500 per treatment. The cost of Dysport, on the other hand, starts out more firmly near the $300 mark.(you can expect to save around 10% with disport basically) It would therefore make sense that over time if Botox feels threatened by Dysports success, the makers of Botox, Allergan, could wind up reducing the cost of Botox to remain competitive.
POTENTIAL SIDE EFFECTS
As with any drug, side effects are possible. Most people, just like with Botox, do not experience any and tolerate the drug quite well. If side effects do occur they are usually very mild and the most common include: nose and throat irritation, headache, injection site pain, injection site skin reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea. These are all the same side effects associated with Botox.
I really could not find any additional side effects or different side effects related to Dysport when I researched for this article.
Like Botox, the labeling for Dysport also contains a boxed warning about the potential distant spread of all botulinum toxin products to other areas of the body.
photo source: http://www.americanhealthandbeauty.com/images/dysportbefore_after.jpg
Where to Go To Get Botox Or Dysport
and what questions you should ask your doctor
Botox and Dysport have been administered to over 21 million people in the past decade with very few complications. However, to be sure your results are of the quality you want and are also complication free, you need to be choosy in where you go to get the injections done. There are many out there, including physicians, who are not trained in medical aesthetics, and who lack lack the training and credentials necessary to ensure safety and excellent results.
First, evaluate the location where you will receive treatment, make sure an actual physician or a certified nurse practitioner who is trained in injectable cosmetics has actually seen you before you proceed. Ask yourself - is the setting a proper medically-equipped office, with safety and sterilization procedures? The proceed by asking some or all of the following questions to your doctor:
How were you trained to do injectable treatments?
Do you regularly provide injectable treatments?
How many people have you treated with a condition similar to mine?
Will you personally inject me? If not, what are the qualifications of the person who will?
Exactly what brand of injectable do you recommend for me?
Is it FDA-approved specifically for cosmetic purposes?
May I see the packaging to verify the brand name?
Are there any precautions I should take before my injectable treatment?
Will anesthetic be necessary? Is it available?
What can I expect to experience after my treatment?
What are the potential risks of treatment?
How long will my results last?
For more information from an unbiased source check out: http://www.injectablesafety.org
Be wary of places the sell Botox or Dyspot by the area such as: forehead = $600, crows feet = $400 and so on. These places are usually ripping you off! You never know just how much of the product you are actually having injected and whether or not it is an effective and proper dose. Botox and Dysport come in UNITS. The unit refers to a measure of activity. Units are how doctors think about and use Botox.
A vial of Botox or Dysport comes with no fluid in it, just dried powder. The doctor's office fills the vial with a certain volume of saline to reconstitute the Botox or Dysport and draws up the amount to be injected into a syringe. Offices use between one and four milliliters of saline for this purpose. So, a one-milliliter syringe might contain between 25 to 100 units of Botox or Dysport. However, some offices dilute their Botox or Dysport much more. I even heard of one doctor who boasts of diluting a vial of Botox with 20 milliliters of saline, so each one-milliliter syringe contains only 5 units of Botox. This saves them money but costs you more so be wary.
There is a huge treatment difference in the results you will notice between 100 units of Botox or Dysport and 5 units of Botox or Dysport. So pin the office down. make them tell you how many units they use and if they are an ethical office, they will have no hesitation telling you.
photo source: http://www.viceaesthetics.com/local/cache-vignettes/L298xH383/pic_botox_1-5b9f0.jpg
Learn More About Botox and Dysport
So if you are really motivated and want to inject youself or others, this guide tells you how to go about doing so.
This book gives all the details anyone could ever want on Botox - from which muscles are the best to have injected to the best way to find and experienced doctor to do the injections to much much more.
Other Uses Of Botox And Dysport
There are quite a few applications that Botox is used for in addition to its use as an injectable cosmetic to reduce wrinkles. These include:
Excessive sweating: Underarm sweating can be eliminated with Botox. The palms, feet, and face can also possibly be treated.
Migraine headaches: Migraine sufferers can get relief by getting Botox injections into the back or sides of the head, forehead or brow area.
Cerebral Palsy and Multiple Sclerosis:Recently, Botox has been used to treat people with Multiple Sclerosis as it lessens muscle contractions that cause spasms and stiffness. Botox has also been used for years to treat children with Cerebral Palsy - it relaxes the muscles that are in spasm..
Muscle spasms and eye twitching: Involuntary eyelid closure, eye twitching, face, jaw and neck spasms, vocal chord spasms, and even stuttering can be lessened with Botox injections.
Lift saggy breasts: Doctors in Europe and Canada are now injecting the pectoral muscles with Botox, to temporarily lift the breast tissue. Unfortunately, this only works on women with smaller breasts.
Sculpt the face: Skilled injectors, can use Botox to sculpt the face, turning up the nose, lifting the eyebrows, and puffing the lip out It can also be used at the corners of the mouth to slightly turn them up, and to relax the muscles in the chin, reducing the appearance of "golf ball chin".
Relax bands in neck: As Some people develop vertical bands in the neck, which can be softened with Botox. The effect can also simulate a neck lift.
Prostate: Men who have had their prostate injected with Botox have seen a decrease in its size, and relief from some of the side effects associated with an enlarged prostate.
TMJ / TMD: Botox can be injected into TMJ muscles to decrease the tension.
Overactive bladder: Doctors can inject Botox into the base of the bladder to relieve the problems associated with an overactive bladder.
Currently Botox is not FDA-approved for some of these treatments and some of the uses for Botox have only been done on a handful of patients.
Like Botox, Dysport has many other medical applications. Some of them approved by the FDA and some of them not. These include include:
Treatment of cervical dystonia(a chronic and painful condition characterized by neck muscles contracting involuntarily, causing abnormal movements and awkward posture of the head and neck.)
Arm spasticity and spasmodic torticollis in adults.
Hemifacial spasm or blepharospasm condition in adults. (a condition which results in uncontrollable blinking and eyelids closure of the affected person due to eyelid muscle gets affected adversely.)
photo source: http://www.realself.com/files/imagecache/blog/injection-28513.jpg
Still Afraid To Try Either Botox or Dysport? - Try these antiwrinkle remidies instead
Dr. Perricone has written numerous books on total skin care and health. As a dermatologist with years of experiecne, he concludes that inflammation is a root cause of wrinkles. This excellent book gives a detailed discussion of how to reduce inflammation at all levels, from the diet you eat to the products you use on your skin. I personally have done the 28 day antiinflammation diet and not only did my skin look great, but I lost 15 lbs too!
What Do You Think About Cosmetic Injectables?
Will You Try Botox or Dysport?