Hello! I live a little bit from Pittsburgh in Hanover, Pennsylvania, but I know some about the city itself. First of all, it's huge and loud, with a population of 312,000 people. The job market throughout most of the state is hurting pretty badly (with Harrisburg just filing for bankruptcy,) and the only jobs that will most likely be available are those in construction/warehouses. The climate is usually hot/humid (anywhere from 80 to 100 degrees F) in the summer and cold/snowy/icy (anywhere from 40 to 15 degrees F) in the winter. Pittsburgh itself is very urbanized and experiences approximately 3,000 violent crimes a year.
Some negative things about Pittsburgh, and Pennsylvania as a whole:
Pennsylvania is an "at-will" state, which means that because you are willfully employed in Pittsburgh, your employee has the right to suspend or terminate you for no reason. (This is probably something that I'll never get used to.) Also, Pittsburgh has a pretty rowdy football team- the Steelers. I don't know if you're a football fan, but there have been some incidences of rioting after games.
Overall, Pittsburgh strikes me as being similar to Baltimore in Maryland, but I know several people that have lived there and they loved it. Best of luck to you in your move, wherever you decide to go!