Marcy...This is a difficult question for garnering just one answer. For me, it depends on where I'm going. Actually, I don't take "vacations," per say......I visit my children or other family or a few friends, who live out of State.
At one point, 2 of my 4 sons (and their families) both lived in Georgia. This made it easy to see all of them in one trip. The majority of the time, I fly. Staying with my kids, makes it unnecessary for me to rent a vehicle.
Two or three times, I have driven, only because I had a willing co-pilot. I've not ever tried this trip by car, on my own and I don't believe I would want to.
My eldest son & family moved from Ga. to California. I think it's going on 2 years now and I've not ventured out to make that LONG trip. Of course, they have come home several times, so I have seen them. Although I don't mind flying, the thought of so many hours in flight, makes me queasy and uneasy.
I have traveled by train, 3 or 4 times and each time, I must admit, was an interesting and pleasant experience. I enjoyed the fact that I had no worries or responsibilities for the trip itself, because I was actually "being delivered," LOL.
I don't mean to sound like a spokesperson for Amtrack, but depending on where you are going, a train is GREAT.....more freedom and options for comfort, than other means of transportation. You can sit and read, or visit with a traveler.....take a nap, view the scenery, get up and move about freely, have a bite to eat in the dining car.....all while going on down the track. No need to stop to do any of this and your not stuck like a sardine in an upright seat, the entire time (as in a plane).
Bottom line....I take a little time to seriously consider my choice of travel, before each and every trip. Then I prepare accordingly, because it is really quite important to "plan" well, for the most enjoyable experience in travel.
Great question, Marcy.....!!