Check out travel blogs that cover safety issues for ideas to consider.
Depending on how long you'll be gone and what season of the year the trip is planned for your home will need to be prepped for not being occupied.
Having a contact person back home for even a short trip is a good idea.
Research the safety concerns of areas you will travel through and stay in. Try to talk to people who have been there rather than depend on promotional sites.
Review and update your will if needed before leaving.