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The Truth Behind Premarin

Updated on July 15, 2009

Premarin mares can be put for adoption


Premarin: not many women really know the truth behind these effective tablets prescribed as hormone replacement therapy. Perhaps a careful evaluation of the wording may give a hint: pregnant mare urine. Indeed, this medication derives from a pregnant mare's urine. There may really not be much to be concerned about giving this a thought. Most every body may imagine a pregnant mare eating grass with a collection cup somehow affixed beneath the mare's tail to collect urine.

Trouble starts however, when the reality is a far cry from a mare enjoying the outside in a pasture. Truth is, the mares employed to collect urine for the distribution of Premarin are kept in very inhumane conditions, turning them from animals with an identity, into simply urine producing machinery with no other purpose in life.

The mares are basically left in small stalls all day with a collection cup placed beneath them. They have minimum range of movement often unable to turn around and lay down comfortably. To make things worse, they are kept this way for six months, usually from October to April with little or no exercise or social interaction with their species.

According to the Humane Society of the United States, there are over 500 PMU farms in North America. with at least 50,000 PMU mares employed in the production of the drug. Of course, after these pregnant mares have donated every ounce of urine they could give, they will give birth to several foal. What happens to the foals then? Many are recycled into the PMU inustry, while another good part of them are slaughtered for their meat.

Fortunately, perhaps it's a good thing after all, the lives of these mares is considerably shortened. From horses typically living 25-30 years, PMU mares generally live only 5-6 years. A high percentage of them having sustained serious leg injuries.

So what can women affected by menopause issues do? There are actually more humane ways of producing the required estrogens and this occurs through the use of plant derived or synthetic estrogens.

Women concerned about the well being of these horses, should consider that pregnant mares are used for producing the following drugs Prempro, Premphase, Prempac, and Premelle. These can present as well under various forms such as pills, creams, injections, patches and vaginal rings.

To make things worse for Premarin users, recent Danish studies demonstrate that Premarin has been linked to higher risks for ovarian cancer. According to the article ''Hormone Therapy Boosts Risk for Ovarian Cancer in Danish Study '' by Nicole Ostrow quoted:

''The researchers found that using hormone therapy results in about one extra case of ovarian cancer for roughly every 8,300 women taking the treatments each year.''

So is taking Premarin really worth it? Apparently it seems to harm many: mares, their foals and now even women taking the medication, leaving benefits merely to the multi bilion dollar PMU industry: the Wyeth company.

An inner look into Premarin

Natural Radiance Estrogen 2 oz Pump Bottle | Soy-Free | Unscented | Made in USA
Natural Radiance Estrogen 2 oz Pump Bottle | Soy-Free | Unscented | Made in USA

Estriol is not a phyto estrogen. Don't confuse phyto estrogens with pure natural estriol USP. The natural estrogen, estriol USP, is made the same way natural progesterone USP is made. Sterol analogues found in many varieties of plants are combined with specific bacteria and the resulting hormone is bio identical in chemical structure to the hormone produced by the human body. Premarin®, conjugated equine estrogen, has been the most commonly prescribed estrogen supplement in the United States and linked to increased cancer rates. Premarin®, Prempro®, Premphase® and Prempac® are synthesized from pregnant mare's urine. Excerpts from "What Your Doctor May Not Tell You About Menopause" by Dr. John R. Lee, M.D. If a three month trial of progesterone plus proper diet and supplements of magnesium and B6 do not relieve hot flashes or vaginal dryness, then low dose natural estrogen may be helpful. All the available evidence we have so far indicates that estriol is the safest estrogen to use to control menopausal symptoms, and that it may even be protective against breast cancer. If you need to supplement some estrogen, you can use a natural estrogen in a cream.

What the Drug Companies Won't Tell You and Your Doctor Doesn't Know: The Alternative Treatments That May Change Your Life--and the Prescriptions That Could Harm You
What the Drug Companies Won't Tell You and Your Doctor Doesn't Know: The Alternative Treatments That May Change Your Life--and the Prescriptions That Could Harm You

Product Description

From one of today's leading authorities on natural medicine comes a provocative look into how the pharmaceutical and medical industries have created our current health crisis and a practical guide to the holistic treatments that may help you and your loved ones.



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    • profile image


      8 years ago

      I am a horse lover and am bewildered as to why this information IS NOT / HAS NOT been reported more in the mainstream media. I am deeply disturbed that this medication has been prescribed for me, that I filled the Rx and now feel extremely mortified that I have helped to perpetuate this incredibly inhumane treatment of horses. I've discovered the ugly truth behind this luxury medicine for people thanks to this web site. HOW CAN THIS BECOME MORE MAINSTREAM INFORMATION??

    • MagicStarER profile image


      9 years ago from Western Kentucky

      Thank you a thousand times for helping educate people about the Premarin industry. These mares are kept constantly in foal to produce as much hormone-laden urine as possible. The mares are kept in stanchions and never allowed to run or play, and are not given proper veterinary care. When they become unable to produce more foals, they are sent to slaughter-houses. The foals are unwanted by-products of this foul industry, and are either, as you say, used to produce more urine for Premarin, or are sent to slaughter-houses for butchering. There are some rescues here in the US that specialize in saving these foals and adopting them out to good homes. Please do not contribute to the agony of these poor horses. Refuse to take Premarin. There are other alternatives that work better!

      Don't forget that menopause is a natural cycle of your body and that a lot of what you are hearing is not true. I went through menopause 12 years ago and did not (& DO not!!!) require any hormone replacement therapy whatsoever. Please learn about natural remedies for your uncomfortable symptoms like hot flashes (I, myself, solved that by simply lowering my thermostat by a few degrees! no pills required!) Eat a healthy, alkaline, organic diet and get plenty of sunlight and rest, reduce stress, and your body will do the rest.

    • Susie Writes profile image


      9 years ago from Northern California

      Thanks for an informative hub! I too am a horse lover/owner and refuse to take Premarin. I do have severe hormonal issues and use a plant based hormone therapy that works quite well. Thanks again for your hub.

    • alexadry profile imageAUTHOR

      Adrienne Janet Farricelli 

      9 years ago from USA

      I did not know either, and I am a big horse lover. I learned about it when working as a pharmacy technician for a big chain pharmacy I had accidentally split a Premarin tablet in half and was smelling the odd smell these pills have.

      My pharmacist caught me and told me ''you are smelling a horse's urine''. I was like "'what?'' Then I went online and found all about it. Of course, they wil not spread the voice too much about it...even though advocates for animal rights are working hard on public awareness.

    • manujkhera profile image


      9 years ago from India

      great info topic...........thanks for sharing.

    • Mighty Mom profile image

      Susan Reid 

      9 years ago from Where Left is Right, CA

      Wow. I had no idea. I did not even know Premarin was made out of mare urine. I just know that hormone replacement therapy for menopause is risky. Luckily mine has been relatively easy.

      Thanks for this eye-opening information. MM


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