ArtsAutosBooksBusinessEducationEntertainmentFamilyFashionFoodGamesGenderHealthHolidaysHomeHubPagesPersonal FinancePetsPoliticsReligionSportsTechnologyTravel

What Is Cushing's Disease?

Updated on December 30, 2023

Cushing's disease is a disease of the endocrine system where the anterior pituitary gland releases a large amount of adrenocorticotropic hormones (ACTH). It is caused by an overdevelopment of the pituitary gland.

What are adrenocorticotropic hormones (ACTH).?

Adrenocorticotropic hormones (ACTH) are hormones secreted by the anterior pituitary gland as a response to stress or other body stimuli.

My sister-in-law had Cushing's disease but is now cured after undergoing first, sphenoidal surgery and then she had to finally undergo gamma knife surgery when the first procedure was not successful.

Functions of the adrenocorticotropic hormone

1. The adrenocorticotropic hormone initiates the release of glucocorticoid steroid hormones from the cells of the adrenal cortex.

2. It initiates the secretion of steroid hormones in two ways: by slower long term action and by rapid short term action.

The adrenocorticosteroid hormone sends signals to the zona farciculata, an area in the adrenal glands to release glucocorticoid steroid hormones. The zona faciculata is the part of the adrenal cortex that is responsible for the production of cortisol, the hormone that regulates glucose metabolism especially in stressful situations.

Glucocorticosteroids are a type of steroid hormones which can be found in all vertebrates.

Cause of Cushing's disease

Cushing's disease is caused by a benign tumor present in the pituitary gland or it could also be caused by an excessive secretion of the corticotropic-releasing hormones.

In the case of my sister-in-law, the cause of her disease is the presence of a benign tumor in her pituitary gland.

Signs and symptoms of Cushing's disease

The symptoms of Cushing's Disease are the same as those of Cushing's Syndrome as both diseases are characterized by having excessive amounts of cortisol, a steroid hormone which was formerly called hydrocortisone.

Cortisol is produced by the adrenal glands particularly in an area called zona fasciculata, one of three layers that make up the adrenal cortex and released by the hypothalamus which is an important part of the human brain.

The common obvious symptoms manifested by my sis-in-law were:

Red face

Round face

Gain in weight

High blood pressure

Fats in the nape

Fatigue

Irrregular menstrual cycle

Short memory span

Easily irritated

Poor focus and concentration

Cushing's disease patients may also experience these less common symptoms:

depression

severe acne

diabetes

insomnia

weakened bones

swollen feet and legs

weakness of the hips and shoulders

hair loss

chronic infection

thinning of the skin

stretch marks



how transphenoidal surgery is performed
how transphenoidal surgery is performed

Treatment of Cushing's disease - Transphenoidal surgery

Treatment of Cushing's disease usually involves what is called transphenoidal surgery where the affected body organ is accessed through the nostril or through an incision made under the upper lip. Complications that can happen during the surgery are bleeding, response to anesthesia, and infection.

In December 2013, my sister-in-law underwent a transphenoidal surgery however in the middle of the procedure there was bleeding in her nose area and the doctor decided to stop the surgery.


Gamma knife radiosurgery - why does it have to be performed?

Gamma knife radiosurgery has to be performed in the following situations:

1) when a tumor has grown in that part of the body that is difficult to reach.

2) when a person is not healthy to undergo a standard brain surgery.

3) when the patient prefers to undergo a non-surgical procedure.

What does gamma knife radiosurgery treat?

Gamma knife radiosurgery is done to treat the following abnormalities:

1) Tumor in the brain

An article published in the New England Journal of medicine in March 1979 reported that there has been no successful treatment yet made of the disease, so far.

The article further reported that bilateral total adrenalectomy can cause Nelson's syndrome and worse can cause death. It also requires hormonal replacement therapy.

Cobalt treatment through pituitary irradiation found to be an effective treatment in children is usually not effective when applied to adults.

What is usually recommended is pituitary irradiation by proton but doctors have found this to be dangerous.

Therapy using bromocriptine, reserpine and antiserotonin drugs has been found to be ineffective in treating the disease.

According to an article in the American Journal of Medicine published in December 2005:

"Surgical resection of tumor is the optimal treatment for all forms of Cushing’s syndrome; bilateral adrenalectomy, medical treatment, or radiotherapy are sought in inoperable or recurrent cases. The medical treatment of choice is ketoconazole. The prognosis is better for Cushing’s disease and benign adrenal causes of Cushing’s syndrome than adrenocortical cancer and malignant ACTH-producing tumors."

© 2014 Zee Formadero

working

This website uses cookies

As a user in the EEA, your approval is needed on a few things. To provide a better website experience, hubpages.com uses cookies (and other similar technologies) and may collect, process, and share personal data. Please choose which areas of our service you consent to our doing so.

For more information on managing or withdrawing consents and how we handle data, visit our Privacy Policy at: https://corp.maven.io/privacy-policy

Show Details
Necessary
HubPages Device IDThis is used to identify particular browsers or devices when the access the service, and is used for security reasons.
LoginThis is necessary to sign in to the HubPages Service.
Google RecaptchaThis is used to prevent bots and spam. (Privacy Policy)
AkismetThis is used to detect comment spam. (Privacy Policy)
HubPages Google AnalyticsThis is used to provide data on traffic to our website, all personally identifyable data is anonymized. (Privacy Policy)
HubPages Traffic PixelThis is used to collect data on traffic to articles and other pages on our site. Unless you are signed in to a HubPages account, all personally identifiable information is anonymized.
Amazon Web ServicesThis is a cloud services platform that we used to host our service. (Privacy Policy)
CloudflareThis is a cloud CDN service that we use to efficiently deliver files required for our service to operate such as javascript, cascading style sheets, images, and videos. (Privacy Policy)
Google Hosted LibrariesJavascript software libraries such as jQuery are loaded at endpoints on the googleapis.com or gstatic.com domains, for performance and efficiency reasons. (Privacy Policy)
Features
Google Custom SearchThis is feature allows you to search the site. (Privacy Policy)
Google MapsSome articles have Google Maps embedded in them. (Privacy Policy)
Google ChartsThis is used to display charts and graphs on articles and the author center. (Privacy Policy)
Google AdSense Host APIThis service allows you to sign up for or associate a Google AdSense account with HubPages, so that you can earn money from ads on your articles. No data is shared unless you engage with this feature. (Privacy Policy)
Google YouTubeSome articles have YouTube videos embedded in them. (Privacy Policy)
VimeoSome articles have Vimeo videos embedded in them. (Privacy Policy)
PaypalThis is used for a registered author who enrolls in the HubPages Earnings program and requests to be paid via PayPal. No data is shared with Paypal unless you engage with this feature. (Privacy Policy)
Facebook LoginYou can use this to streamline signing up for, or signing in to your Hubpages account. No data is shared with Facebook unless you engage with this feature. (Privacy Policy)
MavenThis supports the Maven widget and search functionality. (Privacy Policy)
Marketing
Google AdSenseThis is an ad network. (Privacy Policy)
Google DoubleClickGoogle provides ad serving technology and runs an ad network. (Privacy Policy)
Index ExchangeThis is an ad network. (Privacy Policy)
SovrnThis is an ad network. (Privacy Policy)
Facebook AdsThis is an ad network. (Privacy Policy)
Amazon Unified Ad MarketplaceThis is an ad network. (Privacy Policy)
AppNexusThis is an ad network. (Privacy Policy)
OpenxThis is an ad network. (Privacy Policy)
Rubicon ProjectThis is an ad network. (Privacy Policy)
TripleLiftThis is an ad network. (Privacy Policy)
Say MediaWe partner with Say Media to deliver ad campaigns on our sites. (Privacy Policy)
Remarketing PixelsWe may use remarketing pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to advertise the HubPages Service to people that have visited our sites.
Conversion Tracking PixelsWe may use conversion tracking pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to identify when an advertisement has successfully resulted in the desired action, such as signing up for the HubPages Service or publishing an article on the HubPages Service.
Statistics
Author Google AnalyticsThis is used to provide traffic data and reports to the authors of articles on the HubPages Service. (Privacy Policy)
ComscoreComScore is a media measurement and analytics company providing marketing data and analytics to enterprises, media and advertising agencies, and publishers. Non-consent will result in ComScore only processing obfuscated personal data. (Privacy Policy)
Amazon Tracking PixelSome articles display amazon products as part of the Amazon Affiliate program, this pixel provides traffic statistics for those products (Privacy Policy)
ClickscoThis is a data management platform studying reader behavior (Privacy Policy)