- Diseases, Disorders & Conditions
Dupytren's Contractures - how to release the contractures without surgery
Dupytren's contracture treatment
Curled fingers can now be released without surgery
This condition causes one or more of the fingers to curl and not able to be straightened as hard nodules form around the tendons in the palm of the hand restricting movement of the fingers. This thickening is caused by a change of collagen type from type l to type lll.
The ring finger and fifth finger are most often affected.
The nodules can extend over time into the fingers.
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Maria Badalamente and Lawrence Hurst, the inventors of the collagenase treatment, is on
Dupyrtren's Contracture treatment
Trials of an enzyme (collagenase) injection to treat Dupuytren's contracture have been undertaken in several countries in the past few years.
Some of these are now registered for treatment of Dupuytren's Contractures.
The treatment involves injecting Clostridial collagenase (brand names: Xiaflex or, in Europe, Xiapex) in a doctor's surgery. This weakens the cord (or contracture) over 24 hours. The pateint returns to the surgery the following day when the fingers are manipulated so that the cords break, releasing the fingers to move.
Bent fingers become straight and functional again.
Xiaflex was approved by the United States FDA in February 2010 for treating Dupuytren's contracture and by the European Union in February 2011.
Have you had treatment for Dupytren's Contractures?
Please contribute your experience of surgical or injection treatments as comments below.