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Gamma Oryzanol (muscle-building supplement information)

Updated on August 7, 2007

Gamma oryzanol

Gamma oryzanol is a blend of natural sterols, and ferulic acid esters, usually derived from rice bran oil. Approved in Japan, and very popular there gamma oryzanol has started to become popular in the West as well.

Here is what makes this set of compounds appealing from a health perspective:

  • strong antioxidant activity
  • helps with menopause (esp. related anxiety and hot flashes)
  • helps with anxiety
  • helps counteract an underactive thyroid
  • helps with nausea, vomiting and stomach upset
  • like most edible plant sterols, can help lower serum cholesterol levels
  • very popular with weight-lifters and athletes for its muscle-building and endorphin-releasing properties

Alternate names: Gamma oz, gammariza, oryzanol, oz, calclate, thiaminogen, orizanol (misspelling).

Gamma oryzanol for athletes

Preliminary research seems to suggest that oryzanol can boost endorphin release, and build muscle. Additionally interesting for athletes is gamma oryzanol's reputed ability to help with muscular pain and soreness, and injuries.

Two studies have focused on ferulate (ferulic acid), one of the primary components of gamma oryzanol, for their muscle-building and endorphin-releasing activity. In the first study below, hormone levels in six male endurance runners who took 50mg per day of ferulic acid for three days were measured. While the gamma oryzanol supplements were being taken, levels of endorphins were greater than when the athletes took the placebo. In the second study, six weight lifters took 30mg of ferulic acid daily for eight weeks while four lifters received a placebo. Body weight and strength (measured by one maximum lift) increased among the lifters who took the gamma oryzanol.

  • Bonner B, et al. Influence of ferulate supplementation on postexercise stress hormone levels after repeated exercise stress. J Appl Sports Sci Res. 1990;4:110.
  • Bucci LR, et al. Effect of ferulate on strength and body composition of weightlifters. J Appl Sports Sci Res. 1990;4:110.

Gamma oryzanol is also popular among horse and dog breeders for duplicating many of the same effects of anabolic steroids without "testing positive".


Source Naturals, which carries varying sizes and dosages in its "Dietary Supplement Athletic Series", suggests:

  • For MEN: 60-180mg per day
  • For WOMEN: 60mg per day

Take once daily, preferably on an empty stomach (3 or more hours after a meal) and 45 minutes prior to a workout. May also be taken at night before retiring.


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    • profile image

      John 6 years ago

      I used Gamma Oryzanol back 20 years ago until I couldn't afford it (it was $30 a month then) after moving out on my own and it was great! 2 60mg tabs a day and I worked out moderately for 30 mins every other day and had to back off a bit because my legs & arms were getting too big for my clothes! I would wake up after 6 hours of sleep ready to go, refreshed and when getting a cold I would recover as much as 2x faster then I had before.

      I'm sure not everyone has the same results, but I'm going to start back up on it again and I'll let everyone know how I do now at over age 40 and 70 pounds heavier!

    • profile image

      deadwetdog 6 years ago

      didn't notice any change in stress but never knew it was for stress until reading this page so didn't realy look for it but gives energy and does help with muscle gain greatly also im type 2 diabetic and it seems to help regulate suger levels a bit

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      Lisa  7 years ago

      Gamma Orizinol is FABULOUS FOR ANXIETY and to LOWER the feeling of STRESS!

      If your stress is high due to this recession. Money problems, ADHD kids, etc, THIS STUFF IS GREAT!!! 1 per meal, and I can now handle anything w/no yelling at the kids, arguments w/the husband, HUGE money problems are dealt with with EASE. Also a friend got rid of restless leg syndrom in 2 days w/this. She is amazed. Kids' digestion is MUCH better, as is mine. Try it for 6 weeks and you will never live w/out it again.

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      The Strength Resource 11 years ago

      I have heard that this may help to boost testosterone levels. In fact, this is thought to be the reason for the muscle growth.

      More info can be found at

    • livelonger profile image

      Jason Menayan 11 years ago from San Francisco

      Hi gredmondson. No, I don't take it (I'm not a body builder) and don't know anyone who does. I don't think pregnant women should take it because it does seem to affect hormone levels.

    • gredmondson profile image

      gredmondson 11 years ago from San Francisco, California

      livelonger, do you or anyone you know take gamma oryzanol? Is it safe for pregnant women?

    • vic profile image

      vic 11 years ago

      Nice Hub. Thank you.