ArtsAutosBooksBusinessEducationEntertainmentFamilyFashionFoodGamesGenderHealthHolidaysHomeHubPagesPersonal FinancePetsPoliticsReligionSportsTechnologyTravel

General Effectiveness Of The Treatment Plan Of Amoebiasis Infection

Updated on March 31, 2014

How To Treat Amoebiasis

Source

Treatment Of Amoebiasis

Specific treatment consists of amoebicidal drugs. These may act on the parasites found in the lumen of the gut or on the invasive forms seen in the tissues. They are grouped as luminal amoebicides and tissue amoebicides. Some drugs, however, have action on both the sites. The most effective amoebicides in current uses are given in the following examples below.

  1. Metronidazole: 400mg, 3 times/day orally for 10 days or 800mg twice daily for 5 days.
  2. Emetine: 60 mg intramuscular, daily for 10 days.
  3. Dehydroemetine: 90mg intramuscular daily for 10 days.
  4. Diloxanide furoate: 500 mg, 3 times daily for 10 days.
  5. Chloroquine: 500mg, twice daily for 2 days followed by 250 mg twice daily for 19 days orally.
  6. Tinidazole: 600mg, twice daily for 5 days orally.

The iodohydroxyquinolines which were extensively used to treat chronic intestinal amoebiasis have fallen into disfavor following reports of subacute myelo-optic neuropathy (SMON) mainly from Japan. However, in India, this complication was only rarely encountered.

How To Treat Bacterial Infection of The Stomach And Intestine

Source

The Various Drug Combinations In Amoebiasis Treatment

Metronidazole

This drug has effect on both trophozoites and cysts. It is well-absorbed after an oral dose to produce adequate tissue levels. This drug can be used for the treatment of acute and chronic intestinal amoebiasis and in hepatic amoebiasis. In severe cases, the drug can be used intravenously in a dose of 500mg thrice a day as an infusion. Though, side effects are not serious, they are common. These include distaste in the mouth, anorexia, nausea, abdominal discomfort, vertigo, dizziness and ataxia. Peripheral neuropathy may develop rarely. Peripheral neuropathy may develop rarely. The drug is generally avoided during pregnancy on account of its possible teratogenic effects seen in laboratory animals.

Emetine

It is a powerful amoebicide, effective against the trophozoites in intestinal and extraintestinal amoebiasis. It produces rapid relief in acute amoebic dysentery, liver abscess and other tissue forms of the disease. It is ineffective against cysts. Therefore, it does not eradicate chronic intestinal lesions. Emetine has to be given intramuscularly in a dose of 60 mg/day. The drug is cumulative and, therefore the total dose in a course should be limited to 600 mg. Local necrosis at the site of injection and cardiac toxicity are serious drawbacks. Toxic myocarditis may present with hypotension, cardiac failure, heart block and other serious arrhythmias. Due to this risk, emetine should be avoided in patients with pre-existing heart disease and in old debilitated subjects. Emetine is seldom used now. Only in special indications like hepatic abscess, cutaneous amoebiasis or cerebral and pulmonary amoebiasis. It is given when metronidazole proves unsatisfactory.

Dehydroemetine

It is a synthetic derivative of emtine, which is slightly less potent by has lower cardiotoxicity. It is more widely used than emetine.

In spite of the grave toxic effects, judicious use of emetine and its derivative has saved many patients with advanced severe amoebic lesions.

Dilosanide furoate

It is a safe drug effective only on the intestinal forms of the parasite. It is used in the treatment of acute and chronic intestinal lesions. In amoebic dysentery, the symptoms subside in 5 to 7 days. In chronic intestinal amoebiasis, clearance rates approximate 80 to 90%.

Chloroquine

It has amoebicidal properties in hepatic lesions. This is brought about by the high tissue concentration of the drug about by the high tissue concentration of the drug obtained in the liver. It is effective in the treatment of hepatic amoebiasis along with metronidazole or emetine. It has no action on the trophozoites or cysts in the intestine.

Tinidazole

This drug belongs to the group of nitroimidazole derivatives, structurally related to metronidazole. The therapeutic spectrum is similar to metronidazole, but the drug is more potent. It is also better tolerated.

© 2014 Funom Theophilus Makama

Comments

    0 of 8192 characters used
    Post Comment

    • married2medicine profile imageAUTHOR

      Funom Theophilus Makama 

      4 years ago from Europe

      Yes someonewhoknows... But this has not yet been authenticated with Authority. But some subjects have shown to react severely to garlic (especially) to the point of intestinal bleeding and vomiting. Over here where I work, the reduction in immune system is carefully attributed to the bleeding, so for some of the traditional geriatric patients who instance who would love natural treatments, we are very careful in prescribing such antibiotics and even the plants themselves. So, I can tell u that yes, it does happen, but we cannot conclusively say that these natural plant based antibiotics severely damage our immune system. I hope I have answered your question adequately.

    • someonewhoknows profile image

      someonewhoknows 

      4 years ago from south and west of canada,north of ohio

      What if any effect do think natural plant based antibiotics such as raw garlic & or raw onions some of which are very potent and useful in the gut to eliminate harmful bacteria that can severely damage our immune system through our intestinal track?

    working

    This website uses cookies

    As a user in the EEA, your approval is needed on a few things. To provide a better website experience, hubpages.com uses cookies (and other similar technologies) and may collect, process, and share personal data. Please choose which areas of our service you consent to our doing so.

    For more information on managing or withdrawing consents and how we handle data, visit our Privacy Policy at: https://hubpages.com/privacy-policy#gdpr

    Show Details
    Necessary
    HubPages Device IDThis is used to identify particular browsers or devices when the access the service, and is used for security reasons.
    LoginThis is necessary to sign in to the HubPages Service.
    Google RecaptchaThis is used to prevent bots and spam. (Privacy Policy)
    AkismetThis is used to detect comment spam. (Privacy Policy)
    HubPages Google AnalyticsThis is used to provide data on traffic to our website, all personally identifyable data is anonymized. (Privacy Policy)
    HubPages Traffic PixelThis is used to collect data on traffic to articles and other pages on our site. Unless you are signed in to a HubPages account, all personally identifiable information is anonymized.
    Amazon Web ServicesThis is a cloud services platform that we used to host our service. (Privacy Policy)
    CloudflareThis is a cloud CDN service that we use to efficiently deliver files required for our service to operate such as javascript, cascading style sheets, images, and videos. (Privacy Policy)
    Google Hosted LibrariesJavascript software libraries such as jQuery are loaded at endpoints on the googleapis.com or gstatic.com domains, for performance and efficiency reasons. (Privacy Policy)
    Features
    Google Custom SearchThis is feature allows you to search the site. (Privacy Policy)
    Google MapsSome articles have Google Maps embedded in them. (Privacy Policy)
    Google ChartsThis is used to display charts and graphs on articles and the author center. (Privacy Policy)
    Google AdSense Host APIThis service allows you to sign up for or associate a Google AdSense account with HubPages, so that you can earn money from ads on your articles. No data is shared unless you engage with this feature. (Privacy Policy)
    Google YouTubeSome articles have YouTube videos embedded in them. (Privacy Policy)
    VimeoSome articles have Vimeo videos embedded in them. (Privacy Policy)
    PaypalThis is used for a registered author who enrolls in the HubPages Earnings program and requests to be paid via PayPal. No data is shared with Paypal unless you engage with this feature. (Privacy Policy)
    Facebook LoginYou can use this to streamline signing up for, or signing in to your Hubpages account. No data is shared with Facebook unless you engage with this feature. (Privacy Policy)
    MavenThis supports the Maven widget and search functionality. (Privacy Policy)
    Marketing
    Google AdSenseThis is an ad network. (Privacy Policy)
    Google DoubleClickGoogle provides ad serving technology and runs an ad network. (Privacy Policy)
    Index ExchangeThis is an ad network. (Privacy Policy)
    SovrnThis is an ad network. (Privacy Policy)
    Facebook AdsThis is an ad network. (Privacy Policy)
    Amazon Unified Ad MarketplaceThis is an ad network. (Privacy Policy)
    AppNexusThis is an ad network. (Privacy Policy)
    OpenxThis is an ad network. (Privacy Policy)
    Rubicon ProjectThis is an ad network. (Privacy Policy)
    TripleLiftThis is an ad network. (Privacy Policy)
    Say MediaWe partner with Say Media to deliver ad campaigns on our sites. (Privacy Policy)
    Remarketing PixelsWe may use remarketing pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to advertise the HubPages Service to people that have visited our sites.
    Conversion Tracking PixelsWe may use conversion tracking pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to identify when an advertisement has successfully resulted in the desired action, such as signing up for the HubPages Service or publishing an article on the HubPages Service.
    Statistics
    Author Google AnalyticsThis is used to provide traffic data and reports to the authors of articles on the HubPages Service. (Privacy Policy)
    ComscoreComScore is a media measurement and analytics company providing marketing data and analytics to enterprises, media and advertising agencies, and publishers. Non-consent will result in ComScore only processing obfuscated personal data. (Privacy Policy)
    Amazon Tracking PixelSome articles display amazon products as part of the Amazon Affiliate program, this pixel provides traffic statistics for those products (Privacy Policy)