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Prozac – Weight Loss and Other Appetite Reactions

Updated on April 26, 2019
Jen's Solitude profile image

I've been living with MS for 25+ years and have tried almost every medication available. I have also been evaluated and tested extensively.


Eating Properly

Prozac is doing amazing things as far as my MS fatigue is concerned, but I am also enjoying another unexpected benefit in the form of weight loss help. Prozac is acting as an appetite suppressant. I suppose it means Prozac has now become a vital element of my weight loss program. I foresee the day that I will be able to exercise again and am aware that exercise coupled with a suppressed appetite will prove most useful in losing all the extra pounds being confined to bed has caused me to gain.

I increased my Prozac dosage from 20 mg to 40 mg primarily because of the crash in energy that occurred after approximately 8 hours of Prozac use. My hope was that the increase would allow me to wind down more slowly rather than the sudden drop reminiscent of the steroid crash, where energy is quickly depleted leaving an exhaustion hard to manage.

I found with the Prozac crash I was unable to do anything once the 20 mg left my system. It was strange to have energy all day long only to suddenly lose it at 4:00 pm. I would drop so far that even fixing a meal was impossible, if I mistakenly waited until after 4:00 pm to begin the meal preparation. Given my decreased appetite I often found myself grabbing something quick and convenient, if I ate at all. Not the healthiest weight loss program to implement. Although I still feel an energy drain, it is not as debilitating, I am able to fix myself dinner if need be.


Depending on whom you ask, this next description could be a benefit or a side effect. If you ask me, I call it an added benefit, but if you ask my husband, he would no doubt call it a major side effect. Prozac at 40 mgs definitely makes me more hyper. While it doesn’t always translate into increased physical activity, it most certainly always translates into increased mental activity, especially that part of my brain that activates my speech center.

How bad does it get? So bad that my husband declares he must “get out of here” (our home) because the pills are kicking in. It takes a good hour or so for the Prozac to really get me wound up if I’m having a high energy day.

I begin talking fast and talking OFTEN. My husband told me recently, he has never heard me talk so much. I reminded him he was now talking with someone who wasn’t mentally and physically exhausted, that he hadn’t experienced that person in years, so it wasn’t that I have never talked so much, just that it had been awhile since he’s been around me when I have had so much energy to say so many different things. (See what I mean?)

At times I must confess I do feel a little out of control. It is so exciting to be able to say everything I’m thinking. It is probably hard to understand being too tired to talk, unless you think back to times you have been very sick - so sick you didn’t feel like saying any more than you absolutely had to say. I remember my mom used to tell us kids, “If you have the energy to complain, you’re not that sick.” How true that is. Even as adults, when someone is quiet we know they are very ill. If an adult is whining and complaining, even irritable, we see that as signs of improved health.

Now don’t get me wrong I’m not whining and complaining I’m just talking much more. If it enters my mind I now have the energy to speak my thoughts. I combine my thoughts with pokes at my husband, teasing him, instigating verbal combat, and I do it just because I have the energy . . . finally!

Sometimes he just looks at me and smiles, glad that I am so mentally alert. Other times, if he is tired and I am wound up he seeks out a quite place to hide until the blast from the Prozac begins to wear off. I have discovered when left alone I still find someone to talk to, even if it is the television or just to myself. I think I love the sound of my energetic voice, I sound so “pumped”. I am sure I will adjust to the energy burst soon, for my poor husband’s sake I hope I do so sooner than later, so he can enjoy a little more peace and quiet and not all this kinetic activity which now exists.

Better Quality Sleep

After such a full day of mental and/or physical activity it is nice to report I have no problems falling asleep at night. Quite the contrary I find my body clock seems to be able to reset back to the sleep habits I enjoyed most of my life. Even as a child, I never needed an alarm to wake me up. I rose promptly at 6:00 am every morning. As a teenager and adult I could wake simply by telling myself what time I wanted to wake up the next morning. I used this method when I needed to get up before 6:00 am.

Through the years, as the MS fatigue increased in its intensity, I slowly began to lose that ability. Waking up too tired to get out of the bed is so distressing.

What a pleasure it is to wake up before daylight like the good old days, have the energy to get OUT of bed, grab some coffee and talk with my husband like a normal married couple. We find we appreciate these little moments much more now. We had taken them for granted when I possessed more physical stamina.

Future Hopes and Expectations

I am hoping I will not feel the need to increase my dosage past its present level. I can easily see myself adjusting to this energy setting and allowing it to become my “normal” self. I am still fine-tuning how much I can do and how many days I need to rest so as not to totally deplete my energy reserves. It’s a work in progress, needless to say.

Thus far, I think I can expend myself one day and rest the next. I foresee 3 days of activity using this formula and four days to refill the energy tank. If my theory becomes my fact, I will be delighted.

3 days of energy a week as opposed to 2 hours a day maybe once or twice a week is mind-boggling for my mental comprehension. It means I can do a little bit of everything that is important to me, which means I WILL HAVE MY LIFE BACK! What a way to end this update!

This content is accurate and true to the best of the author’s knowledge and does not substitute for diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed health professional. Drugs, supplements, and natural remedies may have dangerous side effects. If pregnant or nursing, consult with a qualified provider on an individual basis. Seek immediate help if you are experiencing a medical emergency.


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    • profile image


      9 years ago

      I took name brand prozac 20 years ago and it was a dream come true for me. it was very expensive i stuck it out for a year as my DR at that time said a good year of treatment maybe the depression symtoms would not come back. it did. I then was given the generic form and not even close to the same benefits even raised the dose still not the same Ive tried about 7 more antidepressants.,,im now trying generic prozac again really frustrated this itself is depressing,

    • Jen's Solitude profile imageAUTHOR

      Jen's Solitude 

      11 years ago from Delaware

      Tammy thank you for reading it and I'm glad you enjoy my hubs and find them useful.

    • profile image

      Tammy Lochmann 

      11 years ago

      Jen thank you for sharing this. I can use your testimony to maybe help a patient or two. I am enjoying reading your hubs.

    • Jen's Solitude profile imageAUTHOR

      Jen's Solitude 

      11 years ago from Delaware

      Hi Dolores, it has become a running joke around my house now. My husband enjoys warning me he is about to leave, once the pills show they have kicked in. I do believe I'll stop talking so much once I am able to do more physical activities like cleaning and exercising. (smile) Thanks for stopping by.

    • Dolores Monet profile image

      Dolores Monet 

      11 years ago from East Coast, United States

      I guess they have to 'mess around' to try to find the right meds and dosage for you as an individual. Jen, reading about your talking, talking, talking is kind of funny when I see your picture and imagine you talking, talking, talking. Good luck to you and Happy New Year.

    • Jen's Solitude profile imageAUTHOR

      Jen's Solitude 

      11 years ago from Delaware

      Hi Suzanne! I hope the prednisone does the trick. I know Solu Medrol always gives me a boost, then a terrible crash, although it does help with my flares.

      I don't crash as hard with 40 mg of Prozac, which is a big improvement compared to the crash using 20 mgs. Hope it will be of help to you as well. Keep me posted.

    • Suzanne Marcelle profile image

      Suzanne Marcelle 

      11 years ago from Massachusetts

      Just read this hub. Perfect timing! My doctor suggested me going from the 20 mg to 40 mg but didn't wanted to start that just yet because I'm having a possible flare-up as we speak. On prednisone right now but if it doesn't start kicking in I'm going on the Solu-medral. I would LOVE to have my energy back and be able to think and speak clearly again! Thanks for sharing what it's done for you!


    • Jen's Solitude profile imageAUTHOR

      Jen's Solitude 

      11 years ago from Delaware

      Thank you Paradise7, I'm looking forward to increasing my energy and doing more now that I can get moving. :-)

    • Paradise7 profile image


      11 years ago from Upstate New York

      Glad the Prozac is working for you. I understand how happy it makes you to have as a side benefit the weight loss. You do sound a lot better, luv, and I hope you continue to improve.

    • Jen's Solitude profile imageAUTHOR

      Jen's Solitude 

      11 years ago from Delaware

      Nick, just read my hubs about MS to find the answers to your questions.

    • profile image


      11 years ago

      What about trying to lose weight the natural way - by eating less and doing more exercise?

    • Jen's Solitude profile imageAUTHOR

      Jen's Solitude 

      11 years ago from Delaware

      Yes donotfear, others have told me of weight gain> I find I don't crave sweets or junk food as much, that added with the extra activity is why my appetite has been suppressed and I am beginning to shed a pound or two. I had an allergy or two before finding Prozac as well. Nothing like breaking out or itching all over to make you glad you gave a drug a try. ;-) Thanks for the comment!

    • donotfear profile image

      Annette Thomas 

      11 years ago from Northeast Texas

      This is interesting. I've found Prozac to cause weight gain. I want to eat everything in sight. Even the lowest dose, 20mg every other day, I still stay hungry all the time. I got off Prozac recently, and lost 3 pounds. Hyper a lot, energetic, forgetful. Had to get back on situations, ya know? I always develop a gradual weight gain when I'm on antidepressants. I tried Wellbutrin once. It cut my appetite trememdously! But I was allergic to it, broke out in hives. Oh well, I'd rather reap the benefits from the drug and fight the weight gain than get off of it & go 'hyper' again (even though it's a good hyper). Very interesting observation you've got.

    • Jen's Solitude profile imageAUTHOR

      Jen's Solitude 

      11 years ago from Delaware

      Well thank you fastfreta, I look forward to returning the favor and knowing you better too! :-) Happy this enlightened you.

    • fastfreta profile image

      Alfreta Sailor 

      11 years ago from Southern California

      Jen I'm just getting to know you through your hubs, and I find this hub very interesting and enlightening. I look forward to getting to know you better through reading more of your hubs.

    • Jen's Solitude profile imageAUTHOR

      Jen's Solitude 

      11 years ago from Delaware

      Hi Hussains, Thank you for finding my experiences interesting. I appreciate the encouraging comment!

    • Hussains profile image


      11 years ago from Olympia, WA

      Hi Jen, It's an interesting hub and very insightful of what you are experiencing.Its rare to get such a detailed version of personal experience. Thanks for sharing it.Wishing you a happy 2010. :)

    • Jen's Solitude profile imageAUTHOR

      Jen's Solitude 

      11 years ago from Delaware

      Hi handipeep, they certainly are unique, thanks for sharing in my joy that this unique body finally found something that works! ;)


    • profile image


      11 years ago

      so glad that you are having Positive side effects with Meds!! ;) Our bodies are so unique, aren't they? It never ceases to amaze me. I'm so happy for you Dar that Prozac is offering you this hope of a 'new' normal. :)


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