ArtsAutosBooksBusinessEducationEntertainmentFamilyFashionFoodGamesGenderHealthHolidaysHomeHubPagesPersonal FinancePetsPoliticsReligionSportsTechnologyTravel

Thrombophilia: Factor V Leiden, Lupus Anticoagulant, Antiphospholipid Syndrome (APS) And Other Clotting Conditions

Updated on July 8, 2014


Many people have heard of hemophilia but not many people have heard of thrombophilia.  Hemophilia is a condition where a person may have excessive bleeding.  Thrombophilia is the opposite; it is a disease in which a person's blood may clot easily and often.  Thrombophilia can cause a number of serious health problems including deep vein thrombosis, stroke, heart attack, pulmonary embolism, and death. 

A brief video showing the factors involved in clotting

What are the common types of thrombophilia?

Thrombophilia can be either genetic or acquired. Acquired thrombophilia can occur due to liver disease, liver transplant, lupus anticoagulant, and antiphospholipid antibody (anticardiolipin) syndrome. In addition to thrombophilia, other factors can increase clotting. These factors can include pregnancy, bed rest, medication, surgery, and heart attack. Genetic thrombophilia is passed down from parents to offspring. There are a number of these conditions.

Genetic and acquired thrombophilia

APS Awareness

Factor V Leiden (APC resistance, FVL)

Factor V Leiden is a genetic condition that can cause an increased risk of blood clots and pregnancy problems. In FVL, protein C tends to have problems deactivating the factor V protein. The best test for FVL is the genetic blood test. It will check for genes that can cause FVL. It will determine if there are zero, one, or two copies of the faulty gene. This test can be done while on anticoagulation therapy.

Prothrombin 20210

This is a genetic condition that causes the body produce too much of the prothrombinprotein. This is also known as a prothrombin mutation. People can inherit 1 or 2 copies of the mutation. The 1 copy version (heterozygous) is the most common. A genetic blood test can be done to detect this condition and determine if it is heterozygous or homozygous.

Protein C Deficiency

Protein C prevents coagulation. There are a number of inherited and acquired reasons to have low levels of protein C. A blood test will be done to measure protein C in the blood. This test can not be done while the individual is on warfarin/Coumadin as this drug affects protein C levels. There are a number of other factors that can influence protein C. For this reason, protein C blood levels should be measured and analyzed in repeated tests.

Protein S Deficiency

Protein S assists protein C in preventing clots. There are both genetic and acquired reasons for low protein S. A blood test will be done to measure protein S in the blood. This test can not be done while the individual is on warfarin/Coumadin as this drug affects protein S levels. There are a number of other factors that can influence protein S. For this reason, protein S blood levels should be measured and analyzed in repeated tests.

Antithrombin Deficiency

Antithrombin is a molecule that is very important in anticoagulation in mammals. There are both genetic and acquired reasons for antithrombin deficiency. Without enough antithrombin there is increased clotting. There are a large number of blood tests that will be done to determine this condition. Heparins as well as oral anticoagulation (coumadin/warfarin) can affect the numbers on the tests. It is best to be tested when not on anticoaugulation therapy.

Antiphospholipid Syndrome (APS)

APS is an autoimmune condition. The body's immune system attacks various components in the blood. People with this condition have increased clotting. A unique marker of this condition is presence of antiphospholipid (aPL) antibodies or abnormalities in phospholipid-dependent tests of coagulation. Testing will likely include tests for anticardiolipin antibodies, lupus anticoagulant, and antibodies to b2-glycoprotein.


MTHFR is caused by a mutation in a gene that controls the production of MTHFR. MTHFR - (Methylene-tetra-hydro-folate-reductase) is an enzyme found in the cells of our body. It is needed to metabolize (break down) homocysteine, an amino acid found in the proteins you eat. Elevated homocysteine levels are a risk factor for blood clots. If you have MTHRF but do not have elevated homocysteine levels, you are not at risk for a clot. If you have elevated homocysteine levels, it can be controlled with folic acid supplementation. MTHFR can be diagnosed through a genetic test for the gene that causes MTHFR or through a blood test that measures homocysteine levels.


This website uses cookies

As a user in the EEA, your approval is needed on a few things. To provide a better website experience, uses cookies (and other similar technologies) and may collect, process, and share personal data. Please choose which areas of our service you consent to our doing so.

For more information on managing or withdrawing consents and how we handle data, visit our Privacy Policy at:

Show Details
HubPages Device IDThis is used to identify particular browsers or devices when the access the service, and is used for security reasons.
LoginThis is necessary to sign in to the HubPages Service.
Google RecaptchaThis is used to prevent bots and spam. (Privacy Policy)
AkismetThis is used to detect comment spam. (Privacy Policy)
HubPages Google AnalyticsThis is used to provide data on traffic to our website, all personally identifyable data is anonymized. (Privacy Policy)
HubPages Traffic PixelThis is used to collect data on traffic to articles and other pages on our site. Unless you are signed in to a HubPages account, all personally identifiable information is anonymized.
Amazon Web ServicesThis is a cloud services platform that we used to host our service. (Privacy Policy)
CloudflareThis is a cloud CDN service that we use to efficiently deliver files required for our service to operate such as javascript, cascading style sheets, images, and videos. (Privacy Policy)
Google Hosted LibrariesJavascript software libraries such as jQuery are loaded at endpoints on the or domains, for performance and efficiency reasons. (Privacy Policy)
Google Custom SearchThis is feature allows you to search the site. (Privacy Policy)
Google MapsSome articles have Google Maps embedded in them. (Privacy Policy)
Google ChartsThis is used to display charts and graphs on articles and the author center. (Privacy Policy)
Google AdSense Host APIThis service allows you to sign up for or associate a Google AdSense account with HubPages, so that you can earn money from ads on your articles. No data is shared unless you engage with this feature. (Privacy Policy)
Google YouTubeSome articles have YouTube videos embedded in them. (Privacy Policy)
VimeoSome articles have Vimeo videos embedded in them. (Privacy Policy)
PaypalThis is used for a registered author who enrolls in the HubPages Earnings program and requests to be paid via PayPal. No data is shared with Paypal unless you engage with this feature. (Privacy Policy)
Facebook LoginYou can use this to streamline signing up for, or signing in to your Hubpages account. No data is shared with Facebook unless you engage with this feature. (Privacy Policy)
MavenThis supports the Maven widget and search functionality. (Privacy Policy)
Google AdSenseThis is an ad network. (Privacy Policy)
Google DoubleClickGoogle provides ad serving technology and runs an ad network. (Privacy Policy)
Index ExchangeThis is an ad network. (Privacy Policy)
SovrnThis is an ad network. (Privacy Policy)
Facebook AdsThis is an ad network. (Privacy Policy)
Amazon Unified Ad MarketplaceThis is an ad network. (Privacy Policy)
AppNexusThis is an ad network. (Privacy Policy)
OpenxThis is an ad network. (Privacy Policy)
Rubicon ProjectThis is an ad network. (Privacy Policy)
TripleLiftThis is an ad network. (Privacy Policy)
Say MediaWe partner with Say Media to deliver ad campaigns on our sites. (Privacy Policy)
Remarketing PixelsWe may use remarketing pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to advertise the HubPages Service to people that have visited our sites.
Conversion Tracking PixelsWe may use conversion tracking pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to identify when an advertisement has successfully resulted in the desired action, such as signing up for the HubPages Service or publishing an article on the HubPages Service.
Author Google AnalyticsThis is used to provide traffic data and reports to the authors of articles on the HubPages Service. (Privacy Policy)
ComscoreComScore is a media measurement and analytics company providing marketing data and analytics to enterprises, media and advertising agencies, and publishers. Non-consent will result in ComScore only processing obfuscated personal data. (Privacy Policy)
Amazon Tracking PixelSome articles display amazon products as part of the Amazon Affiliate program, this pixel provides traffic statistics for those products (Privacy Policy)
ClickscoThis is a data management platform studying reader behavior (Privacy Policy)