ArtsAutosBooksBusinessEducationEntertainmentFamilyFashionFoodGamesGenderHealthHolidaysHomeHubPagesPersonal FinancePetsPoliticsReligionSportsTechnologyTravel

What is SAM-e?

Updated on May 29, 2013

SAM-e Dietary Supplement

SAM-e is a dietary supplement which is said to help in the treatment of osteoarthritis, depression and liver disease.

A substance which occurs naturally, SAM-e is produced mainly in the liver but can be found in every cell of the human body.

The dietary supplement pronounced Sammy, SAM-e is produced in a laboratory and made into a capsule that is taken by mouth.

SAM-e is said to work as a donor in the parts of the body where not enough SAM-e is being produced.

SAM-e is sold as a dietary supplement in the USA but is widely available as a prescription drug in some European countries such as Russia, Italy, and Germany.

SAM-e has not been approved by the Food and Drug Administration.

Arthritis and SAM-e

Arthritis of the left Knee
Arthritis of the left Knee | Source

SAM-e For Osteoarthritis

Osteoarthritis is caused when cartilage from the joints such as the knee wear away which causes the bones on either side of the joint to rub together, this causes swelling pain and a reduction in mobility and it can occur in any part of the body where two bones are connected by cartilage.

SAM-e is said to help by rebuilding cartilage, reducing swelling, easing pain, reducing stiffness and increasing Mobility.

SAM-e is also said to help in the production of tendons and muscle fibres which also help to reduce the symptoms of osteoarthritis.

Osteoarthritis should always be treated by a medical professional and you should seek the advice of your doctor before taking the supplement.

Anti Depressants and SAM-e

Anti depressants in conjunction with SAM-e in studies 40% of patients showed a significant improvement.
Anti depressants in conjunction with SAM-e in studies 40% of patients showed a significant improvement. | Source

SAM-e Supplement For Depression

There have been many studies carried out on SAM-e and its positive effect on people who suffer from depression, the studies compare the effects of SAM-e with a placebo or sugar pill and although results vary from each of the studies the average results show around forty percent of patients who took the supplement had a significant improvement compared to around fifteen percent of those on the placebo.

Although it is not known why SAM-e works for patients suffering depression it is thought that SAM-e produces neurotransmitters which help to curb depression.

Often anti depressants don't work on patients who suffer from depression but the studies have shown significant improvement in patients who take both SAM-e and antidepressants.

If you are suffering from depression and the anti depressants that you are taking don't seem to have any effect ask your doctors advice on using a SAM-e supplement.

Depression is a serious illness and sufferers should not self treat with SAM-e always consult your doctor before taking.

Liver Disease

Cut section of the liver showing cirrhosis
Cut section of the liver showing cirrhosis | Source

SAM-e For Liver Disease

SAM-e is also said to be effective in treating liver disease and in Europe it is used as a prescription drug for Chronic liver disease.

Research has shown that patients with liver disease and other liver disorders have abnormal methionine metabolism, which depletes SAM-e.

By giving the sufferer synthetic SAM-e this effect was reversed.

Liver disease is often caused by an excess of alcohol over a long period of time and there are very few effective treatments for the disorder. SAM-e according to studies reduced the need for patients to undergo a liver transplant and lowered the risk of death by thirty percent.

Although SAM-e is widely used in Europe on prescription for liver disease it is only available as a dietary supplement in the USA because of " Lack of research"

Liver Disease is a serious illness and sufferers should not self treat with SAM-e always consult your doctor before taking.

SAM-e Supplement Side Effects

SAM-e may react with other medication please consult your doctor if you are on any prescription drugs.
SAM-e may react with other medication please consult your doctor if you are on any prescription drugs. | Source

Side Effects of SAM-e

Although Same is relatively safe to take a minority of users can suffer from side effects from taking it

gas, vomiting, diarrhea, constipation, dry mouth, headache, mild insomnia, anorexia, sweating, dizziness, and nervousness and It can make some people with depression feel anxious.

Do not use SAM-e if you have:

  • Bipolar disorder, SAM-e can cause people with bipolar disorder to change from depression to mania.
  • Parkinson’s disease, SAM-e might make Parkinson’s symptoms worse.
  • If you are going into Surgery, SAM-e might affect the central nervous system. This could interfere with surgery. Stop taking SAM-e at least 2 weeks before a scheduled surgery.
  • Pregnant or Breast Feeding the effects to the unborn baby or breast feeding baby's are unknown please consult your doctor or midwife before using.

Other uses for SAM-e

SAM-e is also said to be effective in the treatment of chronic lower back pain, dementia, Alzheimer's, multiple sclerosis, spinal cord injury, seizures, migraine headache, and lead poisoning.

SAM-e is also said to help in slowing down the aging process by reducing wrinkles and rejuvenating the skin. and it is also said to boost intelligence.


SAM-e is a dietary supplement and if you suffer with any of the ailments above you should always consult your doctor before taking the supplement. Reviews have been good about it as a product but there have also been reviews with negative feelings towards it.


    0 of 8192 characters used
    Post Comment

    • profile image

      Deb Welch 

      5 years ago

      Glad I found this Hub as I was always curious about this supplement but never took it. Here I find out that I could really use it for all my health problems. I will give it a try at least. Thanks - Useful and Interesting Information. Up.

    • Ralph Deeds profile image

      Ralph Deeds 

      5 years ago from Birmingham, Michigan

      Hadacol was popular in my youth in Louisiana. It was said to cure ciatica, lumbago and the piles:

    • AliciaC profile image

      Linda Crampton 

      6 years ago from British Columbia, Canada

      Thank you for the interesting information, jimmy. I've heard of this supplement before, but until now I haven't known much about it. I'm glad that I read your hub!

    • GoodLady profile image

      Penelope Hart 

      6 years ago from Rome, Italy

      I wonder if my doctor will prescribe it for me - I have no more cartilage between knee bones. I suppose I better wait till I seer the specialist next month and ask him about it, but thanks for the great information. Seems amazing.

    • angela_michelle profile image

      Angela Michelle Schultz 

      6 years ago from United States

      You know, I had not heard about this nutrient before. Thanks for educating me. I'm curious if it does the same for anxiety as it does for depression. I don't usually have trouble with the depression, but I do with anxiety.

    • coffeegginmyrice profile image

      Marites Mabugat-Simbajon 

      6 years ago from Toronto, Ontario

      Why, this is scary at the same time very interesting and people could really make use of this information you have shared here, Jim. Thanks for your efforts to putting this together.

    • Sally's Trove profile image


      6 years ago from Southeastern Pennsylvania

      This is a supplement I'd heard of but didn't know much about. A friend of mine has been taking SAM-e for years and wouldn't be without it, but oddly, I never asked her why and she never said, except that she's crabby without it. Guess she and I might have something new to talk about. :) Thanks for this factual overview. Up, interesting, useful.


    This website uses cookies

    As a user in the EEA, your approval is needed on a few things. To provide a better website experience, uses cookies (and other similar technologies) and may collect, process, and share personal data. Please choose which areas of our service you consent to our doing so.

    For more information on managing or withdrawing consents and how we handle data, visit our Privacy Policy at:

    Show Details
    HubPages Device IDThis is used to identify particular browsers or devices when the access the service, and is used for security reasons.
    LoginThis is necessary to sign in to the HubPages Service.
    Google RecaptchaThis is used to prevent bots and spam. (Privacy Policy)
    AkismetThis is used to detect comment spam. (Privacy Policy)
    HubPages Google AnalyticsThis is used to provide data on traffic to our website, all personally identifyable data is anonymized. (Privacy Policy)
    HubPages Traffic PixelThis is used to collect data on traffic to articles and other pages on our site. Unless you are signed in to a HubPages account, all personally identifiable information is anonymized.
    Amazon Web ServicesThis is a cloud services platform that we used to host our service. (Privacy Policy)
    CloudflareThis is a cloud CDN service that we use to efficiently deliver files required for our service to operate such as javascript, cascading style sheets, images, and videos. (Privacy Policy)
    Google Hosted LibrariesJavascript software libraries such as jQuery are loaded at endpoints on the or domains, for performance and efficiency reasons. (Privacy Policy)
    Google Custom SearchThis is feature allows you to search the site. (Privacy Policy)
    Google MapsSome articles have Google Maps embedded in them. (Privacy Policy)
    Google ChartsThis is used to display charts and graphs on articles and the author center. (Privacy Policy)
    Google AdSense Host APIThis service allows you to sign up for or associate a Google AdSense account with HubPages, so that you can earn money from ads on your articles. No data is shared unless you engage with this feature. (Privacy Policy)
    Google YouTubeSome articles have YouTube videos embedded in them. (Privacy Policy)
    VimeoSome articles have Vimeo videos embedded in them. (Privacy Policy)
    PaypalThis is used for a registered author who enrolls in the HubPages Earnings program and requests to be paid via PayPal. No data is shared with Paypal unless you engage with this feature. (Privacy Policy)
    Facebook LoginYou can use this to streamline signing up for, or signing in to your Hubpages account. No data is shared with Facebook unless you engage with this feature. (Privacy Policy)
    MavenThis supports the Maven widget and search functionality. (Privacy Policy)
    Google AdSenseThis is an ad network. (Privacy Policy)
    Google DoubleClickGoogle provides ad serving technology and runs an ad network. (Privacy Policy)
    Index ExchangeThis is an ad network. (Privacy Policy)
    SovrnThis is an ad network. (Privacy Policy)
    Facebook AdsThis is an ad network. (Privacy Policy)
    Amazon Unified Ad MarketplaceThis is an ad network. (Privacy Policy)
    AppNexusThis is an ad network. (Privacy Policy)
    OpenxThis is an ad network. (Privacy Policy)
    Rubicon ProjectThis is an ad network. (Privacy Policy)
    TripleLiftThis is an ad network. (Privacy Policy)
    Say MediaWe partner with Say Media to deliver ad campaigns on our sites. (Privacy Policy)
    Remarketing PixelsWe may use remarketing pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to advertise the HubPages Service to people that have visited our sites.
    Conversion Tracking PixelsWe may use conversion tracking pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to identify when an advertisement has successfully resulted in the desired action, such as signing up for the HubPages Service or publishing an article on the HubPages Service.
    Author Google AnalyticsThis is used to provide traffic data and reports to the authors of articles on the HubPages Service. (Privacy Policy)
    ComscoreComScore is a media measurement and analytics company providing marketing data and analytics to enterprises, media and advertising agencies, and publishers. Non-consent will result in ComScore only processing obfuscated personal data. (Privacy Policy)
    Amazon Tracking PixelSome articles display amazon products as part of the Amazon Affiliate program, this pixel provides traffic statistics for those products (Privacy Policy)