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Gene Soup: the DNA Neighborhood Makes a Difference

Updated on November 4, 2011
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Dallas W Thompson was born in Bakersfield, California to "Grapes of Wrath" descendants. First born son of three siblings of a preacher

Chromosomes Are Territorial in Nucleus

A simple cell. DNA is inside the chromosomes... Chromosomes are territorial and where they are located within the cell influences how the cell functions...
A simple cell. DNA is inside the chromosomes... Chromosomes are territorial and where they are located within the cell influences how the cell functions...
Exploding the above chromosome and looking at human DNA. We have 23 pairs. Males have the small "Y" chromosome and females have the "X" chromosome...
Exploding the above chromosome and looking at human DNA. We have 23 pairs. Males have the small "Y" chromosome and females have the "X" chromosome...

Where Chromosomes Live in Cell; Determines How Cell Funtions...

Chromosomes Group Together In Specific Areas of Our Cells

Location, location, location. The place where our genes are and move in our cells influences how they function, both in health and disease.

Chromosomes prefer specific positions in our cells. They are not randomly scattered in our cells. The chromosome "neighborhoods" reflects the functional state of each chromosome and the gene it carries (DNA is located inside chromosomes). The organization change as a cell's behavior changes and in disease.

Location of Gene Within Cell Nucleaus Provides Clues to Identify Normal, or Diseased Cell

Identifying the locations that genes occupy within the nucleus and seeing how these positions change under different conditions is providing clues to how normal cells function and how some diseases, including cancer begin...

Favored Neighborhoods

Chromosome locations are not always in the same place. They tend to occupy a preferred location inside the nucleus. These arrangements change during dvelopment and in disease. What neighborhood the chromosome lives in influences whether the gene it carries are turned on or off. Genes change their location when their activity changers.

Possible Tool for Cancer Detection

Genome Cell Biologist are still learning the rules about the activity of genes in different places inside the cell nucleus. Where chromnosomes are located plays a central role in so,e cancers. Which chromosomes combine to form cnacer=prompting is influenced by where the chromosomes are located in the nucleus.

By learning where chromosomes typically reside in the nucleus might present opportunities for cancer detection. The position of the genes can help indicate whether a cell is canerous. Gene position soon will become a powerful molecular tool for assisting doctors to diagnose cancer at a very early stage. Certain cancers arise when two or more chromosomes in a cell break (radiation or toxins), and then improperly attach to each other, forming an abnormal combination. Chromosomes near each other combine more often than ones that lie far apart.

Related Information:

http://hubpages.com/hub/DNA-Does-Not-Determine-Entire-Genetic-Fate

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    • dallas93444 profile image
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      Dallas W Thompson 5 years ago from Bakersfield, CA

      Thanks!

    • profile image

      takoua 5 years ago

      i love that this is a great info

    • dallas93444 profile image
      Author

      Dallas W Thompson 6 years ago from Bakersfield, CA

      Healing Touch,

      Thanks! It is a dynamic process....

    • Healing Touch profile image

      Laura Arne 6 years ago from Minnetonka, MN

      Wow, this is great info on geneology. Can't wait to read more.

    • dallas93444 profile image
      Author

      Dallas W Thompson 6 years ago from Bakersfield, CA

      ImChemist,

      Always room for more discusion and information!

    • ImChemist profile image

      ImChemist 6 years ago

      Thanks for this great information i was plan to publish hub like this but i think I'm late!!

    • dallas93444 profile image
      Author

      Dallas W Thompson 6 years ago from Bakersfield, CA

      jacobkuttyta, Thanks for the information. I will check it out! There appears to be a "common ancestor." Also, there appears to be a vast narrowing of the population sometime in the past (forget how long ago)...

    • jacobkuttyta profile image

      jacobkuttyta 6 years ago from Delhi, India

      I found one more site stating the same: http://www.cambridgedna.com/genealogy-dna-genetic-...

    • jacobkuttyta profile image

      jacobkuttyta 6 years ago from Delhi, India

      Please visit the link below for more details

      http://www.africaresource.com/rasta/sesostris-the-...

    • jacobkuttyta profile image

      jacobkuttyta 6 years ago from Delhi, India

      I read somewhere that 97% of DNA is same for people around the world. Also it was confirmed by scientists that as per the DNA study all the people on the earth are from one mother of Ethiopian origin.

      Thanks for the new information

    • dallas93444 profile image
      Author

      Dallas W Thompson 6 years ago from Bakersfield, CA

      vocalcoach,

      Intelligence: Knowing when to stop, knowing a little (not a lot) about what you do not know, saying I do not know, admitting mistakes, learning from my past and most of all, acceptance...

      Thanks for the compliments.

      My heritage is from a proud, and honest stock... people who had/have a work ethics... who are resilient.

    • vocalcoach profile image

      Audrey Hunt 6 years ago from Nashville Tn.

      I enjoy reading your profile. I love "the grapes of wrath" period. The stories, films. What a courageous people! You must be proud to be from that kind of stock.

      I wish I had 5% of your intelligence. Would love more than 5%, but do not want to be greedy :). Great hub here.

      Thanks so much, dallas.

    • dallas93444 profile image
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      Dallas W Thompson 6 years ago from Bakersfield, CA

      Darlene Sabella,

      Yes, where the chromosomes are located within the cell...

      Environmental issues play a major impact upon those with cancers... Notwithstanding the hereidtary factors... I have had melanoma and various skin cancers. I was in the sun a lot as a "youngin."

      Thanks for the "trophies!"

    • Darlene Sabella profile image

      Darlene Sabella 6 years ago from Hello, my name is Toast and Jam, I live in the forest with my dog named Sam ...

      Hello my adorable smart friend, I am going to send this to my daughter, she has a rare cancer that is not in any living relatives in our family, a very serious cancer. So you are saying it is the location of this gene? Not so much a history in the family as much as where this gene is. Hey, that is interesting, Ilove your hubs, rate way up love & peace darski

    • dallas93444 profile image
      Author

      Dallas W Thompson 6 years ago from Bakersfield, CA

      GusTheRedneck,

      Perhaps better than "no genes!" Weepy people like weeping willow trees...

    • GusTheRedneck profile image

      Gustave Kilthau 6 years ago from USA

      Howdy dallas - I learned swome years back that the long-faced, sad and weepy people have "blue genes."

      Gus :-)))