Gene Soup: the DNA Neighborhood Makes a Difference
Chromosomes Are Territorial in Nucleus
Where Chromosomes Live in Cell; Determines How Cell Funtions...
Chromosomes Group Together In Specific Areas of Our Cells
Location, location, location. The place where our genes are and move in our cells influences how they function, both in health and disease.
Chromosomes prefer specific positions in our cells. They are not randomly scattered in our cells. The chromosome "neighborhoods" reflects the functional state of each chromosome and the gene it carries (DNA is located inside chromosomes). The organization change as a cell's behavior changes and in disease.
Location of Gene Within Cell Nucleaus Provides Clues to Identify Normal, or Diseased Cell
Identifying the locations that genes occupy within the nucleus and seeing how these positions change under different conditions is providing clues to how normal cells function and how some diseases, including cancer begin...
Chromosome locations are not always in the same place. They tend to occupy a preferred location inside the nucleus. These arrangements change during dvelopment and in disease. What neighborhood the chromosome lives in influences whether the gene it carries are turned on or off. Genes change their location when their activity changers.
Possible Tool for Cancer Detection
Genome Cell Biologist are still learning the rules about the activity of genes in different places inside the cell nucleus. Where chromnosomes are located plays a central role in so,e cancers. Which chromosomes combine to form cnacer=prompting is influenced by where the chromosomes are located in the nucleus.
By learning where chromosomes typically reside in the nucleus might present opportunities for cancer detection. The position of the genes can help indicate whether a cell is canerous. Gene position soon will become a powerful molecular tool for assisting doctors to diagnose cancer at a very early stage. Certain cancers arise when two or more chromosomes in a cell break (radiation or toxins), and then improperly attach to each other, forming an abnormal combination. Chromosomes near each other combine more often than ones that lie far apart.
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