I would have said Madden in an instance about a year or two ago, but since at this point all there games are the same with no change... I might have to switch directions and go to NBA 2k12. The NBA 2K franchise is in my opinion the best NBA game franchise out there, with their good graphics and realistic playing. And as i said before Madden would have taken the cake a while ago, but not anymore.
NFL 2K series by 2K Sports. ESPN NFL 2K5 was the best experience I have ever had with a NFL football since... well, forever. The defense was a bit shady at times, but it you knew how to run the defense and depended on yourself (unlike Madden)... you could dominate in 2K5. Everything from the presentation, commentating, to the actual feel of the game made the game worth EVERY penny.