DNA Testing for Disease Prevention
Laboratory
Genome Testing
With new technology, it is now possible to have DNA testing (genome screening) for disease prevention. Essentially this means you have your DNA (or genetic code) analyzed to see what your chances are for heart disease, diabetes, cancer and how you might react to common medicines.
The healthy 40-year-old Stephen Quake, a Stanford scientist, his genetic profile was written up in the Lancet after his genes were probed and he was told he was at risk for a heart attack, obesity, diabetes and some cancers, however, he is at low risk for developing Alzheimer disease. One reason Quake was chosen for the testing is he had a first cousin that died mysteriously at age 19. Scientist state a new era of personalized medicine will evolve once they get better at interpreting the data. They think interpreting the data is more difficult than obtaining it.
Scientific Studies and Legislation
For several months 30 scientists studied more than 2 million gene variants in Quake’s DNA. They found genes linked with sudden cardiac death, and others suggesting he might be resistant to the anti-clotting drug clopidogrel.
They suggested Quake start taking cholesterol-lowering medicine, but he declined. Quake’s testing cost $50,000, but scientist look for a day where the testing will cost $1000 in about 3 years. The research has been funded by the U.S. National Institute of General Medical Sciences and the National Heart, Lung and Blood Institute and others.
Some think there are ethical dilemmas to be considered. Perhaps more legislation will be necessary to protect an individual’s personal information. After all, an employer might not give you a job if they were privy to this type of information, or a life insurance company might refuse your insurance application.
Also, many people may not want to know the intimate details of their genome. At this time many people have had their full genomes sequenced.
Stephen Quake
Stephen Quake's Decisions
Many scientists think it will help people live a healthier life. For instance, if you are more likely to develop heart disease you might eat healthier; take cholesterol medicine earlier and exercise. Stephen Quake stated, “You know, the chance of dying is 100 percent, it's just a question of how and when, right? I think this sort of points to an interesting thing about personal genomes.
You have to have a bit of a strong stomach for it." In his case now that he knows he has a link to sudden cardiac death, he remains athletic and plans to get echocardiograms, ultrasonograms and stress tests periodically so doctors can look for any ominous changes in his heart. He states he will start taking cholesterol-lowering drugs if his cholesterol rises into an unhealthy range, as right now it is normal.
Testing for Cancer Risk Video
Human Genome (DNA)
Testing to Assess Cancer Risk
There are some specific tests available now at a reasonable price for such things as the abnormality of the breast cancer gene. I have a friend who studies genealogy as I do. She is of Swedish descent and she noticed that most of her ancestors died of some type of cancer. Then she got breast cancer and had a bilateral mastectomy.
The human genes BRCA1 and BRCA2 belong to a class of genes known as tumor suppressors. Mutation of these genes has been linked to breast and ovarian cancers. This is true for men getting breast cancer as well. A woman’s lifetime risk of developing breast and/or ovarian cancer is greatly increased if she inherits a harmful mutation in BRCA1 or BRCA2. You will see multiple members in a family with cancer and these cancers quite often happen before menopause. The difference is about 120 out of 1000 would normally develop breast cancer but with the mutation 600 out of 1000 are at risk.
There are state laws in place to protect your privacy with this testing. There is also genetic testing for colon cancer. These are genetically inherited diseases.
Mayo Clinic Minute
BRCA1 and BRCA2
If you decide to get tested as you know many in your family have had breast or ovarian cancer and if your test is positive then you have some choices to make. One option is more frequent, careful screening. Some women chose prophylactic surgery, which is surgically removing as much of the at-risk tissue as possible and some have their ovaries and fallopian tubes removed, but that is not even a 100% guarantee that you will remain free of the disease but it certainly improves your odds.
There are also medications such as Tamoxifen that has been shown in numerous studies to reduce your risk of developing breast cancer by about 50% for those at increased risk. To get more information about cancer genetics, check out http://www.cancer.gov/search/geneticsservices/.
My friend only had to have a mastectomy on one breast but because she had the testing she opted to have both removed at the same time. I think I would have made the same decision in that case. Through her experience, she has been contacting all her relatives, many in the US and some in Sweden. They have been getting the testing and several are positive.
One man just decided to have a colonoscopy done early and they found very early stage cancer which saved his life. Some women have found early-stage breast cancer, so her awareness and encouragement to her family to get tested have literally saved the lives of her extended family.
Laboratory
In Summary
Genetic testing has a long way to go, yet look at the great strides that have already happened. Lives are being saved from cancer and maybe that will happen with heart attacks, strokes and other diseases as the scientists learn more about interpreting data. Even Mayo Clinic is now offering DNA testing for patients.
DNA testing for disease prevention is definitely a part of our future.
This content is accurate and true to the best of the author’s knowledge and does not substitute for diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed health professional. Drugs, supplements, and natural remedies may have dangerous side effects. If pregnant or nursing, consult with a qualified provider on an individual basis. Seek immediate help if you are experiencing a medical emergency.
Comments
hey, i made a hub also about DNA and its medical uses, you guys might want to check it out
The new technology of DNA testing will help us prevent diseases and this will be good for humanity. But, someone will go over the line, and we will have to deal with it. Good hubpage.
My dearest Pam...
As always you write thought provoking and interesting hubs! I do enjoy them and learn from them very much! Indeed your research is always quite thorough, which makes your hubs even more appealing! Great theme! Bookmarked, Rated up and Stumbled!
Warmest regards and infinite heavenly blessings,
Al
Pamela enjoyed the hub - I can see the benefits but also worry what big brother or big money may try to do with this kind of knowledge in the wrong hands.
A wealth of information. Your research is always amazing. DNA is a fascinating subject. You did an amazing job on this hub. Thanks so much for keeping me up on the latest technological data in regards to DNA. Once again, there is always something new to learn. I always look forward to reading your hubs. Happy Mother's Day!
Great Job!
Sage
One more thing... Happy Mother's Day to you!
Aww.. the ever evolving DNA debate..you know something Pamela, I'm not sure I would want to know if I had something so bad with no cure at hand. So I guess you could say I'm sitting on the fence with this one. You provided some information I had not realized yet.. so give me a few days...My opinions may change. Helpful hub, rated up!
I dropped by to say Happy Mothers Day Pam, Maita
Pamela99: This is really very interesting and informative. I look forward to further findings in this area.
BTW: As a nurse, I am certain that you know many physicians were already utilizing the internet even before our current President came into office, as they have found it to be a source to quickly obtain test results, etc., as well as treat the patient in a timely manner. I do understand the concern, however. It seems the higher the technology, the greater risks there are in certain areas. This could also be said for the genome studies. This type of knowledge of new discoveries could be 'deadly' in the wrong hands and/or in one with the wrong mindset. Peace to us all.
I am glad to read this information. New technology for the medicine world. You comes with useful information. Good work, Pamela. As usual I rate this hub. Thumbs Up for you.
Great Hub! Up-rated! You find the coolest subjects to write about. I wish I had half your talent. Keep up the good work!
This was a very interesting topic to write about. It amazes me at the new things that are being done these days. Thank you for sharing all this interesting information.
Pamela99 this is excellent work and something I did not realize was being done. Great information and yes; God had it all planned out and he uses humans to reveal it.
Thanks so much for the hub.
Very interesting hub. Thanks
this is awesome explanation and a topic for health hub, I learned a lot from it specially cancer testing DNA risk, Maita
I've read a little about this, but I learned more here. Great job!
Did not know about this fully. Written excellently I enjoyed learning about this.
pamela
Does Barrack have BRaCk1 or BRaCk2 genes and do they identify people from Kenya?
What a hub. It is amazing what scientists can accomplish and have accomplished. Sometimes too much information is not a good thing. I would hate for this type of information to get in the wrong hands. Everything is moving so fast these days. In the long run it is probably a good thing, but scary at the same time. Maybe they should check Obama, who knows what they would find?????????????
very interesting - I can see how it can be both a good and a bad thing to know all of this information. It can certainly help people take preventative measures but I think it has the potential to add a lot of stress and worry as well. Also I can see how the information could be used against a potential employee or somone getting health insurance. It will be interesting to see what happens with this as time goes on.
Interesting hub, but honestly sometimes too much information is a terrible thing!
Great Hub !
You have done some wonderful research for this !
Amazing and Kudos to you.
Ron
As Always Also a2z50
DNA was a great discovery and is a wonderful help in many ways. Thank you for great hub.
The technology is a little over my head, but you did a wonderful job making it understandable!!
Excellent Pamela, after my daughter found out about her breast cancer she is doing this kind of research for her nine year old. The never what's her daughter to suffer and go through the hard times she is going through. Awesome hub and advise and thank you for sharing this with us.
Hi Pam. Great hub. The problem is that the gene defines a "susceptibility", not an inevitability to disease,inmost cases In most cases,there will have to be an "irritant" to promote the disease. Then, of course, some will test the DNA of a fetus to avoid "inferior" genotypes. In which case, geniuses like Stephen Hawking would have been long ago eliminated to humanity's bereft.
I believe that the great Hippocrates said "Let food be medicine, and medicine be your food." And, you know, it can be as simple as that, but the AMA doesn't want you to find out about that.
The progress in understanding the Genome and the potential to develop better diagnostics and better treatments leads me to believe that we'll soon be seeing improved health and longer life expectancies. The implications are tremendous and probably will change (eventually) our way-of-life. One of the reasons I disliked the Health Care Bill was the potential for government interference (control?) with advances related to what we'd learned. In fact, such advancement is a Constitutional responsibility of the Congress (Article I, Section 8 - 'promote the Progress of Science and useful Arts'), as opposed to the 'everybody pays' approach to Health Care.
Imagine where we'd be today if Microsoft had been government controlled.
Interesting information. To test or not to test is the question. Genetic testing can raise moral issues like you mention but it can also be very helpful in saving lives. Rated it up!
Pamela - this is a well-written article.
I can foresee a potential DNA scenario now. One day, not too far in the future, young people may be required to have their respective DNA tested before attempting to conceive a child. Orwell's "1984" is not far away.
Magnificent and very informative article here. I agree that it CAN be a good thing, but again there is the privacy issue. With the government controlling all healthcare, it will become MUCH more difficult to keep your private medical issues private.
I watch lots of crime tv, and I was thinking that there may eventually come a time where a DNA sample can enable the cops to KNOW the hair color, eye color, and skin color of offenders when a sample of DNA is available. Just a crazy thought I had!!
Interesting. I have a son in law that is a geneticist. This is the new field in that career. It is very interesting. I have another daughter that just had an untra-sound done on her unborn baby. It shows some abnormality in the development of the heart. So...how do you react? What do you do? The only action that can be taken now is to worry. Is that good? We decided to realize there might be a risk, and know that we can adjust. Many live with abnormalities of the heart. Worry isn't going to help anything. Would they consider abortion? No. What good it this knowledge now?
Hi Pamela
I found this hub really interesting as it follows on from the hub I've just written on The Blood Type Diet. I think our bodies will hold the key to solving a lot of our health issues. Rated up!
Amber:)
DNA testing, how cool is that? I would rather live in fear of big brother and the insurance companys finding out about my DNA, than die from fear and not knowing ...
Pamela, Fascinating I am such a Science Geek! Love this hub. DNA is a remarkable science and it has only just begun to open doors of knowledge. I look forward to more on this subject. Thanks and Peace :)
I am most concerned about the universal Internet health records that the Obama administration is promoting; that the insurance companies will find a way to use it against you, if they discover something they don't like or that they think they can charge more for because it supposedly puts you into a higher-risk category!
I didn't used to think that way. I guess I'm just getting tired of getting beaten up by bureaucracies.
DNA is more than a wonderful thing. It is sufficient proof to me that there is a Divine Creator.
Pamela,
I'm a big baby anyway I don't think I'd participate in DNA testing there are just some things I don't want to know!!!!!!!!
Thanks for the excellent overview of this new technology. Technology is evolving rapidly especially in terms of medicine. They say the time of neuro-enhancements to increase the capacity of the human brain is just around the corner.
We rejoice is all the blessings God has made available to us. Thanks for this timely hub PAM.
Forever His,
Many people will take advantage of this new technology. Thanks for sharing.
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