ArtsAutosBooksBusinessEducationEntertainmentFamilyFashionFoodGamesGenderHealthHolidaysHomeHubPagesPersonal FinancePetsPoliticsReligionSportsTechnologyTravel

Is Estrogen Receptor/Progesterone Receptor status of Breast Cancer related to Race?

Updated on September 6, 2015

Adjuvant Hormonal Therapy for Estrogen Receptor Positive Early Stage Breast Cancer

Estrogen Receptor Assay being performed

Source

What are Estrogen Receptors/Progesterone Receptors?

Oestrogen receptors are protein molecules found inside the cell for which estrogen has an affinity. Estrogen is a hormone helping in the development of secondary sexual characteristics in females. All the cells in the body do not have estrogen receptors.

The tissues with cells having estrogen receptors are called target tissues for the action of estrogen. When estrogen combines with estrogen receptors in target tissues, it may help in the growth and multiplication of cells in that tissue.

Otherwise, it can be stated that cells with estrogen receptors require estrogen for its growth and multiplication. Progestrone receptor is also a protein molecule found in some cells of the body, where the hormone progesterone can get attached and may cause the cell to grow.

What is the Significance of having Estrogen Receptors on Breast Cancer Cell?

Patients having estrogen receptors on the breast cancer cells are said to have estrogen receptor positive status. It is advantageous to have estrogen receptors and progestron receptors on the breast cancer cells if you have breast cancer, because then it can be treated with hormone therapy.

So we can say breast cancer patients who are estrogen receptor positive have a sluggish course to their disease and have better prognosis. Such tumors grow with the help of hormones. So if the hormone supply to these tumor cells is prevented, their growth can be controlled and recurrence avoided.

Breast Cancer: Estrogen Receptors

Estrogen Receptor Positive Breast Cancer

Do you think Estrogen Receptor Positive Breast Cancer has Better Prognosis?

See results

How is Estrogen Receptor Positive and Progesterone Receptor Positive Tumors Treated?

Estrogen receptor positive and progesterone receptor positive tumors are treated with anti estrogen therapy. The aim of treatment is to lower the level of estrogen in the body and to prevent estrogen from attaching to the estrogen receptors thereby preventing cell signalling and growth.

Anti estrogen therapy has proved to be good in preventing recurrence of breast cancer and the most common drug used is Tamoxifen. Other drugs include raloxifene, anastrozole, exemestane, letrozole and fulvestrant. Tamoxifen belongs to the category of Selective Estrogen Receptor modulator (SERM) and is given orally.

Is Estrogen Receptor/Progesterone Receptor Status of Breast Cancer Related to Race?

So we have seen that it is advantageous to have hormone receptor positive breast tumors, because of the treatment options available. But, there are some recent studies stating that the hormone receptor status varies according to the race of the patient.

A study conducted by Dr. Ward and colleaugues found that there are more number of black women compared with white women having estrogen- or progesterone-receptor (ER/PR) negative breast cancer. They also found that black women had a 2.26 times chance of getting diagnosed with ER/PR-negative than with ER/PR-positive breast cancer compared to white women.

Another study conducted by Department of Pathology, Tata Memorial Hospital, Mumbai, India showed that, out of the 798 breast tumors studied, 46.5% were Estrogen receptor negative and progesterone receptor negative.

There is yet another study published in BMCCancer 2010,assessed the United States National Cancer Institute's Surveillance Epidemiology and End Results (SEER) Cancer program and found that Indian and Pakistani women in U. S have higher frequency of ER/PR negative breast cancer

Many more such studies are required under different settings to reach at a conclusion and to explore the reasons for these racial variations in hormone receptor status.

Comments

    0 of 8192 characters used
    Post Comment

    • thumbi7 profile imageAUTHOR

      JR Krishna 

      6 years ago from India

      Thank you, Shonali

    • profile image

      shonali 

      6 years ago

      i guess it wil be of great usefulness to all ,miss thumbi

    • thumbi7 profile imageAUTHOR

      JR Krishna 

      6 years ago from India

      Sorry, tirelesstraveler to hear about your disease. Seen your profile. Appreciate your zeal and enthusiasm. Love you.Hugs.

    • tirelesstraveler profile image

      Judy Specht 

      6 years ago from California

      Living with cancer makes me interested in hubs like this.

      Good start.

    working

    This website uses cookies

    As a user in the EEA, your approval is needed on a few things. To provide a better website experience, hubpages.com uses cookies (and other similar technologies) and may collect, process, and share personal data. Please choose which areas of our service you consent to our doing so.

    For more information on managing or withdrawing consents and how we handle data, visit our Privacy Policy at: https://hubpages.com/privacy-policy#gdpr

    Show Details
    Necessary
    HubPages Device IDThis is used to identify particular browsers or devices when the access the service, and is used for security reasons.
    LoginThis is necessary to sign in to the HubPages Service.
    Google RecaptchaThis is used to prevent bots and spam. (Privacy Policy)
    AkismetThis is used to detect comment spam. (Privacy Policy)
    HubPages Google AnalyticsThis is used to provide data on traffic to our website, all personally identifyable data is anonymized. (Privacy Policy)
    HubPages Traffic PixelThis is used to collect data on traffic to articles and other pages on our site. Unless you are signed in to a HubPages account, all personally identifiable information is anonymized.
    Amazon Web ServicesThis is a cloud services platform that we used to host our service. (Privacy Policy)
    CloudflareThis is a cloud CDN service that we use to efficiently deliver files required for our service to operate such as javascript, cascading style sheets, images, and videos. (Privacy Policy)
    Google Hosted LibrariesJavascript software libraries such as jQuery are loaded at endpoints on the googleapis.com or gstatic.com domains, for performance and efficiency reasons. (Privacy Policy)
    Features
    Google Custom SearchThis is feature allows you to search the site. (Privacy Policy)
    Google MapsSome articles have Google Maps embedded in them. (Privacy Policy)
    Google ChartsThis is used to display charts and graphs on articles and the author center. (Privacy Policy)
    Google AdSense Host APIThis service allows you to sign up for or associate a Google AdSense account with HubPages, so that you can earn money from ads on your articles. No data is shared unless you engage with this feature. (Privacy Policy)
    Google YouTubeSome articles have YouTube videos embedded in them. (Privacy Policy)
    VimeoSome articles have Vimeo videos embedded in them. (Privacy Policy)
    PaypalThis is used for a registered author who enrolls in the HubPages Earnings program and requests to be paid via PayPal. No data is shared with Paypal unless you engage with this feature. (Privacy Policy)
    Facebook LoginYou can use this to streamline signing up for, or signing in to your Hubpages account. No data is shared with Facebook unless you engage with this feature. (Privacy Policy)
    MavenThis supports the Maven widget and search functionality. (Privacy Policy)
    Marketing
    Google AdSenseThis is an ad network. (Privacy Policy)
    Google DoubleClickGoogle provides ad serving technology and runs an ad network. (Privacy Policy)
    Index ExchangeThis is an ad network. (Privacy Policy)
    SovrnThis is an ad network. (Privacy Policy)
    Facebook AdsThis is an ad network. (Privacy Policy)
    Amazon Unified Ad MarketplaceThis is an ad network. (Privacy Policy)
    AppNexusThis is an ad network. (Privacy Policy)
    OpenxThis is an ad network. (Privacy Policy)
    Rubicon ProjectThis is an ad network. (Privacy Policy)
    TripleLiftThis is an ad network. (Privacy Policy)
    Say MediaWe partner with Say Media to deliver ad campaigns on our sites. (Privacy Policy)
    Remarketing PixelsWe may use remarketing pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to advertise the HubPages Service to people that have visited our sites.
    Conversion Tracking PixelsWe may use conversion tracking pixels from advertising networks such as Google AdWords, Bing Ads, and Facebook in order to identify when an advertisement has successfully resulted in the desired action, such as signing up for the HubPages Service or publishing an article on the HubPages Service.
    Statistics
    Author Google AnalyticsThis is used to provide traffic data and reports to the authors of articles on the HubPages Service. (Privacy Policy)
    ComscoreComScore is a media measurement and analytics company providing marketing data and analytics to enterprises, media and advertising agencies, and publishers. Non-consent will result in ComScore only processing obfuscated personal data. (Privacy Policy)
    Amazon Tracking PixelSome articles display amazon products as part of the Amazon Affiliate program, this pixel provides traffic statistics for those products (Privacy Policy)