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Burn Off Fat with Fatostatin

Updated on January 2, 2013

Fatostatin Works on Mice. Will it Work on You?

A brand new study published recently in the journal, Chemistry and Biology, reports that a new man-made chemical, fatostatin, prevented mice from putting on weight even when they were allowed to eat whatever they wanted. This remarkable drug lowered their production of fat and at the same time lowered the rodents' cholesterol and blood sugar levels.

Unlike cholesterol-lowing statins on the market today which block a single enzyme, this new chemical, fatostatin, "hits fat from the very beginning," stated Motonari Uesugi, co-author of the study and a researcher at Kyoto University, Japan.

Now I can eat all the cheese I want.
Now I can eat all the cheese I want.

Goodbye Diet Programs

Imagine being able to do away with Weight Watchers, Jenny Craig, Atkins, and all the other diets that keep you from eating the foods you love. How does this new chemical work its magic? It has the ability to influence many of the genes involved in fat production, as well as having a positive impact on a collection of risk factors including obesity, high cholesterol and insulin resistance - all at one time.

The obese mice in the study who were injected with fatostatin showed a noticeable reduction in their weight and their respective livers were a healthy-looking red compared to their untreated obese counterparts. To quote Dr. Uesugi, "When fatostatin was injected, the mice did not get fat even when they ate a lot, and we did not see any obvious side or toxic effects."


Fatosatin is Powerful

Fatostatin appears to have the power to turn off fat production. Yes - actually turn off fat production - making it a powerful weapon against obesity. But don't run to your phone to call your doctor for a magic prescription of fatostatin yet. You will have to be patient since research on the drug is in its earliest stages.

For years various researchers have been searching for a pill to help people fight obesity. There are some anti-obesity drugs on the market at present but they have harmful side effects and patients often stop using them.

Uesugi's laboratory has samples of more than 30,000 chemicals and is testing them on human and mouse cells. Fatostatin appeared to stop fat production by "turning" specific genetic switches.

Uesugi added that injection of such a drug is not an option for those with chronic metabolic diseases such as those that cause obesity. More research needs to be done in order to develop a pill that will be safe for humans.

Is Fatostatin Safe?

Regarding safety, "fatostatin's activity on 63 genes, many of which have nothing to do with fat synthesis, raised questions about potential side effects, particularly if the chemical is ingested over many years," stated Dr. Nicholas H.E. Mezitis, Assistant Professor of Clinical Medicine at Columbia University College of Physicians and Surgeons who is familiar with the study findings.

Still the various researchers seem to agree that there is definitely promise in the area of targeting genetic switches that turn on fat production as fatostatn appears to do. So we will have to wait until this intriguing chemical is approved for ingestion by humans. However, I do have a suggestion for the pharmaceutical marketing team. Are you sure you want to call this new, magical substance, fatostatin? If you want your sales to soar, consider changing the name to slimo-statin, thino-statin, or even skinny-statin.

© Copyright BJ Rakow 2010, 2013. All rights reserved.

B. J. Rakow, Ph.D., Author, "Much of What You Know about Job Search Just Ain't So." - a serious book about job search written in a light-hearted manner.

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    • drbj profile imageAUTHOR

      drbj and sherry 

      5 years ago from south Florida

      Fatostatin seems to be a viable drug for weight loss, ps, but my most recent research indicates that this 'marvelous' substance is manufactured in the U.K. by Tocris Bioscience, and as yet, does not appear to be approved in the U.S. by our enigmatic Federal Drug Administration.

      The most effective way to weight loss may still be counting calories. Sorry about your recent health problem. Hope all is healing and you are well for this new year ... and all the rest. Thanks for the Angels.

    • pstraubie48 profile image

      Patricia Scott 

      5 years ago from sunny Florida

      I wonder. I will need to check this out. My desire is to get my weight in a healthy range. If there is something to help besides my will power I will consider it. I have a hernia which hurts when I eat and hurts when I don't eat. I hope to have some relief from it in a few weeks. I am checking into this product. Thanks for the heads up.

      Happy New Year ...

      Sending Angels to you:) ps

    • drbj profile imageAUTHOR

      drbj and sherry 

      7 years ago from south Florida

      I already know you have a very wise mama, Audrey. How do I know? Because the 'apple doesn't fall far from the tree.' And she was spot on with her advice. I try to hide the salt shaker, too. It's the chocolate I can't hide - it disguises itself as a chocolate chip cookie!

      Thanks for the visit and your sweet comment.

    • vocalcoach profile image

      Audrey Hunt 

      7 years ago from Idyllwild Ca.

      My very wise mama taught me when I was young to keep my caloric portions small and "play hard". It has always worked for me. As you say...burn off more that you eat to lose weight or maintain. You will never be hungry if you load up on veggies. There are some fantastic recipies on the internet for a variety of ways to make them very tasty. Hide the salt shaker! Great hub...vocalcoach

    • drbj profile imageAUTHOR

      drbj and sherry 

      7 years ago from south Florida

      What a great movie title - "The Mouse that Ate a House!" Love it. Copyright it stat!

    • nicomp profile image

      nicomp really 

      7 years ago from Ohio, USA

      That mouse ate a house!

    • drbj profile imageAUTHOR

      drbj and sherry 

      7 years ago from south Florida

      I think the plural is mices.

      Wanna see a photo of a really sweet looking OBESE mouse? Visit my hub: https://hubpages.com/health/MSG-Fat-Rats-and-Us

    • nicomp profile image

      nicomp really 

      7 years ago from Ohio, USA

      if I was an obese mouse I could take fatostatin and become more attractive to mouses of the opposite gender.

    • drbj profile imageAUTHOR

      drbj and sherry 

      7 years ago from south Florida

      Nah, nicomp, I luv you just the way you are!

    • nicomp profile image

      nicomp really 

      7 years ago from Ohio, USA

      If only I was an obese mouse...

    • drbj profile imageAUTHOR

      drbj and sherry 

      8 years ago from south Florida

      There hasn't been any news about Fatostatin this year according to the health and medical journals I follow, so they may still be testing the product.

      If you are in generally good health otherwise, you might want to check out (Google) the "Cookie Diet." Good luck.

    • habee profile image

      Holle Abee 

      8 years ago from Georgia

      Any more news? Exercise is difficult for me due to nerve damage and an old injury.

    • drbj profile imageAUTHOR

      drbj and sherry 

      8 years ago from south Florida

      Thank you, katie, for your visit and your observant comment. Delighted that you felt it was a "great read." Love your hubs, too.

    • katiem2 profile image

      katiem2 

      8 years ago from I'm outta here

      As you mentioned in your comments the only way to loose weight and know you'll be safe is to burn off more than you put in... Great read! :)

    • drbj profile imageAUTHOR

      drbj and sherry 

      8 years ago from south Florida

      Hello, weredragonlady - how nice to meet you. Thank you for visiting.

      This new drug does seem to hold promise for individuals like yourself since it acts on the genetic switches that turn on fat production. Your "switch" unlike that of your sister's, might require just such a jump-start.

      You might want to Google fatostatin each month to learn when clinical trials are completed and the drug reaches our market. Best of luck.

    • profile image

      weredragonlady 

      8 years ago

      hi,

      i just read a snippet in woman's world about this new development and its really exciting to know that some people/dr/researchers, realize that for some of us it isn't all about calories vs calories burned.

      my family eats exactly what i do, and im 285 and my little sister is 120. that's with me drinking water only and her drinking ice tea with real sugar. so dr cant explain it, and i would do anything to be in this drugs human trials. to see if something can finally work for me.

    • drbj profile imageAUTHOR

      drbj and sherry 

      8 years ago from south Florida

      Hi, habee.

      I'm going to check on the status of Fatostatin and I'll get back to you.

      In the meantime, increase your physical activity. Walk more stairs and park further away from the store you are visiting.

    • habee profile image

      Holle Abee 

      8 years ago from Georgia

      I hope I live long enough to see this on the market!

    • drbj profile imageAUTHOR

      drbj and sherry 

      8 years ago from south Florida

      Perhaps they say they love you as you are because they love you and don't want to stress you. But being overweight is the worst stress you can have on your heart, and I know you know that with your medical background.

      Take a look at my hub: Obesity is Worldwide and try one of the 4 diets. I think the Mediterranean plan might work the best for you. Or the South Beach diet. I have faith in you. You CAN do it!

    • Austinstar profile image

      Lela 

      8 years ago from Somewhere near the center of Texas

      What loved ones? They seem to love me fat. At least that's what I think when they shove all the good food towards my face. Ha! And What Will Power??? I obviously do not know the meaning of the words. I am currently trying to force myself to exercise again. Why does it have to be so hard?

    • drbj profile imageAUTHOR

      drbj and sherry 

      8 years ago from south Florida

      Hi, Austinstar, how nice of you to visit.

      The only proven way to lose weight is to take in fewer calories than you expend. If you eat, let's say, 2000 calories worth of food each day, but you use up only 1500 calories, you can NOT lose weight. That is a proven fact in weight loss.

      You can lose weight with diet WILL if you cannot use diet pills. But no one ever said it was easy. You have to possess a will of iron and get the support of your loved ones. I wish you success.

    • Austinstar profile image

      Lela 

      8 years ago from Somewhere near the center of Texas

      Shoot I wouldn't care if they called it Obesostatin if it worked! I also don't care if they put the other diet companies out of work. Sheesh, nothing works for me.

      Diet pills really worked once apon a time, but they won't let me take them long term. I can't believe being fat long term is better than taking pills long term. What's the difference?

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