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Xerostomia in Systemic Disorders | Autoimmune Diseases | Diabetes

Updated on July 11, 2010

Buy Orahealth Xylimelts for Dry Mouth Relief

Many types of systemic disorders cause decreased salivary flow, which lead to development of dry mouth syndrome or xerostomia. Some diseases such as autoimmune diseases, diabetes mellitus, hypertension, neurological disorders, and depression cause progressive destruction of parenchyma often irreversibly. Other times there may be affected nerves or vessels causing temporary effects and reversibility. Autoimmune diseases, which induce dry mouth or xerostomia, are Sjögren’s syndrome, lupus erythematosus, rheumatoid arthritis, and scleroderma. Common clinical features in all these diseases can be observed as oral mucosa dryness as well as dryness of ocular, vaginal, pharyngeal, laryngeal, and nasal mucous membranes. Out of all these disorders, Sjögren's syndrome is the one that most affects the mucous membranes. Sjögren’s syndrome is a chronic inflammatory autoimmune disease characterized by progressive replacement of the parenchyma of the lacrimal glands and salivary by an inflammatory infiltrate. It can be seen alone as primary Sjögren syndrome or in association with other autoimmune disorders like lupus erythematosus, rheumatoid arthritis, scleroderma, primary biliary cirrhosis, and vasculitis.

Dry mouth in autoimmune disorders and diabetes.
Dry mouth in autoimmune disorders and diabetes.

When a dentist suspects the presence of dry mouth syndrome or xerostomia, the patient is referred for a biopsy of the salivary glands to be performed under the lower lip. The patient also undergoes special serological tests like IgG antibodies, anti Ro/SS-A and anti Ro/SS-B34, and rheumatoid factor.

Another disease that commonly causes xerostomia is diabetes. According to recent research conducted on diabetic and nondiabetic patients, it has been found that the total saliva of diabetic patients not controlled is approximately one third to half the amount of saliva of non-diabetics. The uncontrolled diabetic patients may have some clinical manifestations of disease namely polydipsia, polyphagia, polyuria causing the sensation of dry mouth. What occurs in uncontrolled diabetic patients who have xerostomia is progressive destruction of parenchyma, which can also sometimes affect blood vessels and nerves.

The above factors modify the secretion of salivary flow by different mechanisms including the interruption of autonomic nerve function, interference with ductal cells of salivary glands, cytotoxicity causing indirect effects such as vasoconstriction or vasodilation, and disturbance of fluid and electrolyte balance. These can also cause physical trauma to the salivary glands and nerves.

Now read some Tips on Dealing with Xerostomia or Dry Mouth Syndrome

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    • soni2006 profile imageAUTHOR

      Rajinder Soni 

      8 years ago from New Delhi, India

      It's my pleasure Steve.

    • SteveoMc profile image

      SteveoMc 

      8 years ago from Pacific NorthWest

      I feel for those people, I hope that they can get good treatment options. Thanks for the eye opener.

    • soni2006 profile imageAUTHOR

      Rajinder Soni 

      8 years ago from New Delhi, India

      Dry mouth syndrome is a problems that affects many people and affects most who are undergoing some sort of medicine treatment and are under stress. Also people who don't eat or drink frequently have complained about this. Thanks a lot for adding your personal experience about Lithium causing dry mouth to you. Also thanks for purchasing Orahealth Xylimelts Mints for dry mouth relief. You will get some benefit from it. Best of luck.

    • schoolgirlforreal profile image

      schoolgirlforreal 

      8 years ago

      ps I want to let you know I purchased the Orahealth Xylimelts Mints, plus something else for total $28.00. That should bring you in a slight revenue,,this is the 1st time I've ever done that!! Great topic here. I really t hink this will help me, thx

    • schoolgirlforreal profile image

      schoolgirlforreal 

      8 years ago

      This is interesting. I wonder how dry mouth affects people. For instance, I've taken Lithium which causes dry mouth. It has caused multiple cavities and teeth problems, like root canals, AND in my mind-thou no doctor has told me- I find it hard to chew and swallow food, for my mouth stays dry (unless I down alot of water or drink) and it seems my salivary glands aren't helping to break the food down, or help moisten it to help me swallow it. It takes me about 4x the amount of time to finish a meal than someone else.

      WHY DON'T DOCTORS TELL ME THIS? THEY ALWAYS ASK WHAT MEDS I'M ON.....It's like I have to figure it all out myslef.

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