Well, the old adage is that there are three things to consider in real estate: location, location and location. In residential housing, that means suitability to your lifestyle: if you have (or plan to have) kids, then the quality of the schools is a big consideration. Relevant amenities are a similar question--do you want to be close to arts and cultural opportunities? Close to the country? Shopping? Your job?
And what about the community you will be moving into? Is the neighborhood economically stable? Environmentally clean? Safe?