Take a shower and change into clean clothes. There are so many compromises you have to make with cleanliness while traveling (public bathrooms are the worst) and when I get home I want to feel clean and then relax.
I know this is going to sound strange, but I use my own bathroom. I have severe OCD, and hotel bathrooms leave me on edge. It's like a signal that I can feel comfortable again--in bathrooms I know are clean and on sheets I know are appropriately washed.