I think AIDS would be the answer. Having worked with many people with AIDS, I witnessed the disease process. Things are much better now, and AIDS is more manageable than it was in the '80s, but I there is still a stigma attached. I edited a deposition not long ago about a woman who was approached by employees at work who told her she should quit, that they didn't want to work with someone with AIDS. And this is after all the education and information has been available or a very long time. Being "shunned" is a terrible thing. Yes, AIDS, to me, is the worst.