I would assume they do not have The Lord in their heart. if you have a personal relationship with Him that does not mean that you won't have any troubles but He will help you through what ever comes your way. Life is not always easy but with The Lord near you know that He will never forsake you , we can't always say that about people.
There are just over 7 billion people in the world and probably 1/2, or far more, are uhappy at any given time. Meaning that there are 3.5 Billion answers to your question as asked.
For your question to be valid you will have to refine it to one segment.
Even then the reasons I might have for being unhappy or not happy, big difference, are probably going to be very different than another's.
Because people have different angles to view questions or life. For example, when missing another people who is not around, some people will feel unhappy or painful because they focus the mind on the point that they cannot see the one any more, but some other people will avoid unhappy feeling because they are happy to have "the feeling of miss" inside. They know that there are people who deserve them to miss, which makes them more confident, firmer and richer in mind.
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