The documents you created with the programs will be fine as long as they aren't stored somewhere among the program files that are going to be deleted. Like if you have them on the desktop or on a USB stick they'll be fine.
But any settings that are stored in the program files will disappear unless you find a way to export them. For example, if you created a special template, that might get erased. Or if you're uninstalling a browser you'll have to export your bookmarks to avoid losing them. Hope that makes sense.
You can save all your files and documents created in the Google Drive or into a pen drive (USB), etc. and then safely uninstall and re-install your programs. I always save my files on Google Drive. It is a very safe place. One benefit is you can access your files from anywhere in the world when you store them in the Google Drive.
Often after trying to open Outlook or Explorer; often on net. Sometimes freezes without warning (can't do anything). Sometimes crashes completely and get the blue screen.what is wrong with my computer? ...