I would simply say that it is about someone who is ired/irked by something.
My mom and dad used the saying " what's got your britches in an uproar?", it's like asking what's wrong or what made you upset.
Nose all out of joint? Would be similar to that.
I use to say, "What got your nose bent out of shape?", which I picked up from someone else when I was younger, like a teen in school. Sorry, if I can't remember where it came from, but the reason for that is a much longer story, which I really don't need to get into on this topic.